Sutured Clear Corneal Incision: Wound Apposition and Permeability to Bacterial-Sized Particles

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dc.contributor.author May, William N.
dc.contributor.author Castro-Combs, Juan
dc.contributor.author Kashiwabuchi, Renata T.
dc.contributor.author Tattiyakul, Woranart
dc.contributor.author Qureshi-Said, Saima
dc.contributor.author Hirai, Flavio [UNIFESP]
dc.contributor.author Behrens, Ashley
dc.date.accessioned 2016-01-24T14:31:21Z
dc.date.available 2016-01-24T14:31:21Z
dc.date.issued 2013-03-01
dc.identifier http://dx.doi.org/10.1097/ICO.0b013e31824d0d45
dc.identifier.citation Cornea. Philadelphia: Lippincott Williams & Wilkins, v. 32, n. 3, p. 319-325, 2013.
dc.identifier.issn 0277-3740
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/36052
dc.description.abstract Purpose: To determine the effects of single radial or horizontal suture placement in 2-step clear corneal incision (CCI) wound apposition and permeability to particles of India ink.Methods: Five fresh human globes were included. Two 25-gauge needles connected to a saline solution bag and to a digital manometer were inserted through the limbus, 120 degrees apart from each other. Four 2-step CCIs (2.75 mm wide and 3 mm length) were constructed in each cornea. Incisions were divided into 3 groups: single radial suture (SRS), single horizontal suture (SHS), and unsutured group. Optical coherence tomography (OCT) was performed before and after suture placement. With a preset 10 mm Hg intraocular pressure (IOP), India ink was applied to the incision site and a standardized sudden IOP fluctuation was induced. OCT and superficial images were recorded before and after suture placement. India ink inflow and internal and external CCI gapping were outlined and measured by planimeter.Results: the area and linear distance of India ink inflow after pressure challenge in all study groups were higher when compared with pre-pressure measurements; however, this increase was significant in the SRS and SHS groups (P < 0.05). Additionally, SRS placement significantly increased inner wound gapping (P = 0.018), and SHS significantly widened outer wound gape (P = 0.02).Conclusions: Well-constructed unsutured 2-step CCI seems to be more efficient at preventing bacterial-sized particles inflow during sudden changes in IOP, and it seems to offer better wound apposition as assessed by OCT. en
dc.description.sponsorship May Vision Foundation, Los Angeles, California
dc.description.sponsorship Research to Prevent Blindness, New York, New York
dc.description.sponsorship Johns Hopkins University School of Medicine, Baltimore, Maryland
dc.description.sponsorship Research to Prevent Blindness Althouse Special Scholars Award
dc.description.sponsorship Fight for Sight, New York, New York
dc.format.extent 319-325
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof Cornea
dc.rights Acesso restrito
dc.subject cataract surgery en
dc.subject clear corneal incision en
dc.title Sutured Clear Corneal Incision: Wound Apposition and Permeability to Bacterial-Sized Particles en
dc.type Artigo
dc.contributor.institution Univ So Calif
dc.contributor.institution Johns Hopkins Univ
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ So Calif, Keck Sch Med, Doheny Eye Inst, Los Angeles, CA 90033 USA
dc.description.affiliation Johns Hopkins Univ, Sch Med, Wilmer Eye Inst, Baltimore, MD 21205 USA
dc.description.affiliation Universidade Federal de São Paulo, Paulista Sch Med, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Paulista Sch Med, São Paulo, Brazil
dc.identifier.doi 10.1097/ICO.0b013e31824d0d45
dc.description.source Web of Science
dc.identifier.wos WOS:000314818700017



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