Hyaluronic acid concentration in postmenopausal facial skin after topical estradiol and genistein treatment: a double-blind, randomized clinical trial of efficacy

Hyaluronic acid concentration in postmenopausal facial skin after topical estradiol and genistein treatment: a double-blind, randomized clinical trial of efficacy

Author Patriarca, Marisa Teresinha Autor UNIFESP Google Scholar
Barbosa de Moraes, Andrea Regina Autor UNIFESP Google Scholar
Nader, Helena B. Autor UNIFESP Google Scholar
Petri, Valeria Autor UNIFESP Google Scholar
Maciel Martins, Joao Roberto Autor UNIFESP Google Scholar
Teixeira Gomes, Regina Celia Autor UNIFESP Google Scholar
Soares, Jose Maria Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: the aim of this work was to compare the effects of estradiol and genistein treatment on hyaluronic acid (HA) concentration in postmenopausal facial skin.Methods: in this study, 30 postmenopausal women were evaluated in a prospective, randomized, double-blind trial. the volunteers were postmenopausal women treated in the Gynecology Department of the Federal University of São Paulo. the participants were divided into two groups: group E, treated with 0.01% 17 beta-estradiol gel (n = 15), and group G, treated with 4% genistein gel (isoflavones, n = 15). the treatment lasted for 24 consecutive weeks. Preauricular skin biopsies were performed for each participant at baseline (E1 and G1) and after treatment (E2 and G2) to evaluate HA concentration in tissue. the materials were processed using immunohistochemical and biochemical methods.Results: After 24 weeks of treatment, HA concentration increased in both groups, but the effect was greater for estradiol treatment than for genistein treatment.Conclusions: Our data suggest that both treatments may enhance HA concentration in postmenopausal skin but that estrogen produces results that are greater than those produced by isoflavones.
Keywords Postmenopausal skin
Genistein gel
17 beta-Estradiol gel
Hyaluronic acid
Language English
Sponsor Consejo Nacional de Desarrollo Cientifico y Tecnologico
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Funda cao de Amparo a Pesquisa do Estado de São Paulo
Grant number Funda cao de Amparo a Pesquisa do Estado de São Paulo: 2011/12417-8
Date 2013-03-01
Published in Menopause-the Journal of the North American Menopause Society. Philadelphia: Lippincott Williams & Wilkins, v. 20, n. 3, p. 336-341, 2013.
ISSN 1072-3714 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 336-341
Origin http://dx.doi.org/10.1097/gme.0b013e318269898c
Access rights Closed access
Type Article
Web of Science ID WOS:000315603200017
URI http://repositorio.unifesp.br/handle/11600/36050

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