Use of Grape Polyphenols Against Carcinogenesis: Putative Molecular Mechanisms of Action Using in Vitro and in Vivo Test Systems

Use of Grape Polyphenols Against Carcinogenesis: Putative Molecular Mechanisms of Action Using in Vitro and in Vivo Test Systems

Author Gollucke, Andrea P. B. Google Scholar
Aguiar, Odair Autor UNIFESP Google Scholar
Barbisan, Luis Fernando Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Institution Univ Catolica Santos
Universidade Federal de São Paulo (UNIFESP)
São Paulo State Univ
Abstract Polyphenols are present in foods and beverages and are related to sensorial qualities such as color, bitterness, and astringency, which are relevant in wine, tea, grape juice, and other products. These compounds occur naturally in forms varying from simple phenolic acids to complex polymerized tannins. Thus, it is reasonable to expect that grape-derived products elaborated in the presence of skins and seeds, such as wine and grape juice, are natural sources of flavonoids in the diet. Carcinogenesis is a multistep process that is characterized by genetic, epigenetic, and phenotypic changes. With increasing knowledge of these mechanisms, and the conclusion that most cases of cancer are preventable, efforts have focused on identifying the agents with potential anticancer properties. the use of grape polyphenols against the carcinogenesis process seems to be a suitable alternative for either prevention and/or therapeutic purposes. the aim of this article is to show the molecular data generated from the use of grape polyphenols against carcinogenesis using in vivo and in vitro test systems.
Keywords cancer
carcinogenesis
grape polyphenol
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2013-03-01
Published in Journal of Medicinal Food. New Rochelle: Mary Ann Liebert Inc, v. 16, n. 3, p. 199-205, 2013.
ISSN 1096-620X (Sherpa/Romeo, impact factor)
Publisher Mary Ann Liebert Inc
Extent 199-205
Origin http://dx.doi.org/10.1089/jmf.2012.0170
Access rights Closed access
Type Article
Web of Science ID WOS:000316051800002
URI http://repositorio.unifesp.br/handle/11600/36047

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