Molecular Adaptations to Concurrent Training

Molecular Adaptations to Concurrent Training

Author Souza, E. O. de Google Scholar
Tricoli, V. Google Scholar
Roschel, H. Google Scholar
Brum, P. C. Google Scholar
Bacurau, A. V. N. Google Scholar
Ferreira, J. C. B. Google Scholar
Aoki, M. S. Google Scholar
Neves-, M. Google Scholar
Aihara, A. Y. Google Scholar
Correa Fernandes, A. da Rocha Autor UNIFESP Google Scholar
Ugrinowitsch, C. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Stanford Univ
Abstract This study investigated the chronic effects of concurrent training (CT) on morphological and molecular adaptations. 37 men (age = 23.7 +/- 5.5 year) were divided into 4 groups: interval (IT), strength (ST) and concurrent (CT) training and a control group (C) and underwent 8 weeks of training. Maximum strength (1RM) and muscle cross-sectional area (CSA) were evaluated before and after training. Muscle samples were obtained before the training program and 48 h after the last training session. VO2max improved in 5 +/- 0.95 % and 15 +/- 1.3 % (pre- to post-test) in groups CT and IT, respectively, when compared to C. Time to exhaustion (TE) improved from pre- to post-test when compared to C (CT = 6.1 +/- 0.58 %; IT = 8.3 +/- 0.88 %; ST = 3.2 +/- 0.66 %). 1RM increased from pre-to post-test only in ST and CT groups (ST = 18.5 +/- 3.16 %; CT = 17.6 +/- 3.01 %). Similarly, ST and CT groups increased quadriceps CSA from pre-to post-test (6.2 +/- 1.4 %; 7.8 +/- 1.66 %). the p70S6K1 total protein content increased after CT. the ST group showed increased Akt phosphorylation at Ser473 (45.0 +/- 3.3 %) whereas AMPK phosphorylation at Thr172 increased only in IT group, (100 +/- 17.6 %). in summary, our data suggest that despite the differences in molecular adaptations between training regimens, CT did not blunt muscle strength and hypertrophy increments when compared with ST.
Keywords maximum dynamic strength
muscle hypertrophy
interval training
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 2007/02738-6
FAPESP: 2010/51428-2
FAPESP: 2009/03143-1
CNPq: 152658/2011-4
CNPq: 470207/2008-6
CNPq: 303162/2008-2
Date 2013-03-01
Published in International Journal of Sports Medicine. Stuttgart: Georg Thieme Verlag Kg, v. 34, n. 3, p. 207-213, 2013.
ISSN 0172-4622 (Sherpa/Romeo, impact factor)
Publisher Georg Thieme Verlag Kg
Extent 207-213
Access rights Closed access
Type Article
Web of Science ID WOS:000315166200004

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