Sleep and epilepsy: Exploring an intriguing relationship with a translational approach

Sleep and epilepsy: Exploring an intriguing relationship with a translational approach

Author Matos, Gabriela Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Scorza, Fulvio A. Autor UNIFESP Google Scholar
Cavalheiro, Esper A. Autor UNIFESP Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The relationship between sleep and epilepsy has been well established. There is a high prevalence of sleep disturbances in epilepsy, which are associated with a decreased quality of life of individuals with epilepsy. in view of this fact, preclinical research is necessary to address many gaps in knowledge. for instance, it is well known that sleep deprivation can trigger seizures; however, this is a complex pathophysiological event. in this context, there are many valuable animal models of epilepsy that reproduce clinical symptoms and can be used. Investigations using animal models that simulate clinical epilepsy are imperative. Furthermore, preclinical studies that reveal mechanisms related to sleep-epilepsy interactions are very important. Results of such studies can, in turn, improve the understanding of epilepsy itself and can be useful in developing new antiepileptic drugs and preventive measures to control seizures. Preclinical research should be performed using a translational framework with experimental designs that can lead to advances in the quality of life of individuals with epilepsy. in view of the fact that more than 50 million of people are affected by epilepsy around the world, understanding the relationship between sleep and epilepsy is imperative.This article is part of a Special Issue entitled the Future of Translational Epilepsy Research. (c) 2012 Elsevier Inc. All rights reserved.
Keywords Sleep
Sleep disturbance
Epilepsy
Preclinical research
Rodents
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 10/15110-8
FAPESP: 12/05396-7
Date 2013-03-01
Published in Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 26, n. 3, p. 405-409, 2013.
ISSN 1525-5050 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 405-409
Origin http://dx.doi.org/10.1016/j.yebeh.2012.12.003
Access rights Closed access
Type Review
Web of Science ID WOS:000316663900025
URI http://repositorio.unifesp.br/handle/11600/36040

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