Nitric oxide donor superparamagnetic iron oxide nanoparticles

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dc.contributor.author Molina, Miguel M.
dc.contributor.author Seabra, Amedea B. [UNIFESP]
dc.contributor.author Oliveira, Marcelo G. de
dc.contributor.author Itri, Rosangela
dc.contributor.author Haddad, Paula S. [UNIFESP]
dc.date.accessioned 2016-01-24T14:31:20Z
dc.date.available 2016-01-24T14:31:20Z
dc.date.issued 2013-03-01
dc.identifier http://dx.doi.org/10.1016/j.msec.2012.10.027
dc.identifier.citation Materials Science & Engineering C-materials for Biological Applications. Amsterdam: Elsevier B.V., v. 33, n. 2, p. 746-751, 2013.
dc.identifier.issn 0928-4931
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/36038
dc.description.abstract This work reports a new strategy for delivering nitric oxide (NO), based on magnetic nanoparticles (MNPs), with great potential for biomedical applications. Water-soluble magnetic nanoparticles were prepared through a co-precipitation method by using ferrous and ferric chlorides in acidic solution, followed by a mercaptosuccinic acid (MSA) coating. the thiolated nanoparticles (SH-NPs) were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM), and vibrating sample magnetometry (VSM). the results showed that the SH-NPs have a mean diameter of 10 nm and display superparamagnetic behavior at room temperature. Free thiol groups on the magnetite surface were nitrosated through the addition of an acidified nitrite solution, yielding nitrosated magnetic nanoparticles (SNO-NPs). the amount of NO covalently bound to the nanoparticles surface was evaluated by chemiluminescense. the SNO-NPs spontaneously released NO in aqueous solution at levels required for biomedical applications. This new magnetic NO-delivery vehicle has a great potential to generate desired amounts of NO directed to the target location. (C) 2012 Elsevier B.V. All rights reserved. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent 746-751
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Materials Science & Engineering C-materials for Biological Applications
dc.rights Acesso restrito
dc.subject Magnetite nanoparticles en
dc.subject Nitric oxide en
dc.subject S-nitrosothiol en
dc.subject Iron oxide nanoparticles en
dc.subject Nanomaterials en
dc.subject Nanotechnology en
dc.title Nitric oxide donor superparamagnetic iron oxide nanoparticles en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade Estadual de Campinas (UNICAMP)
dc.description.affiliation Univ São Paulo, Inst Fis, BR-05508090 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Ciencias & Terra, BR-09972270 Diadema, SP, Brazil
dc.description.affiliation Univ Estadual Campinas, Inst Quim, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Ciencias & Terra, BR-09972270 Diadema, SP, Brazil
dc.description.sponsorshipID FAPESP: nr. 2001/10125-0
dc.description.sponsorshipID CNPq: nr. 310209/2010
dc.description.sponsorshipID CNPq: 309390/ 2011-7
dc.identifier.doi 10.1016/j.msec.2012.10.027
dc.description.source Web of Science
dc.identifier.wos WOS:000315761700025



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