Nitric oxide donor superparamagnetic iron oxide nanoparticles

Nitric oxide donor superparamagnetic iron oxide nanoparticles

Autor Molina, Miguel M. Google Scholar
Seabra, Amedea B. Autor UNIFESP Google Scholar
Oliveira, Marcelo G. de Google Scholar
Itri, Rosangela Google Scholar
Haddad, Paula S. Autor UNIFESP Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Campinas (UNICAMP)
Resumo This work reports a new strategy for delivering nitric oxide (NO), based on magnetic nanoparticles (MNPs), with great potential for biomedical applications. Water-soluble magnetic nanoparticles were prepared through a co-precipitation method by using ferrous and ferric chlorides in acidic solution, followed by a mercaptosuccinic acid (MSA) coating. the thiolated nanoparticles (SH-NPs) were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM), and vibrating sample magnetometry (VSM). the results showed that the SH-NPs have a mean diameter of 10 nm and display superparamagnetic behavior at room temperature. Free thiol groups on the magnetite surface were nitrosated through the addition of an acidified nitrite solution, yielding nitrosated magnetic nanoparticles (SNO-NPs). the amount of NO covalently bound to the nanoparticles surface was evaluated by chemiluminescense. the SNO-NPs spontaneously released NO in aqueous solution at levels required for biomedical applications. This new magnetic NO-delivery vehicle has a great potential to generate desired amounts of NO directed to the target location. (C) 2012 Elsevier B.V. All rights reserved.
Palavra-chave Magnetite nanoparticles
Nitric oxide
S-nitrosothiol
Iron oxide nanoparticles
Nanomaterials
Nanotechnology
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Número do financiamento FAPESP: nr. 2001/10125-0
CNPq: nr. 310209/2010
CNPq: 309390/ 2011-7
Data de publicação 2013-03-01
Publicado em Materials Science & Engineering C-materials for Biological Applications. Amsterdam: Elsevier B.V., v. 33, n. 2, p. 746-751, 2013.
ISSN 0928-4931 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 746-751
Fonte http://dx.doi.org/10.1016/j.msec.2012.10.027
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000315761700025
Endereço permanente http://repositorio.unifesp.br/handle/11600/36038

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