Incorporation of bioactive glass in calcium phosphate cement: An evaluation

Incorporation of bioactive glass in calcium phosphate cement: An evaluation

Author Renno, Ana Claudia Muniz Autor UNIFESP Google Scholar
van de Watering, F. C. J. Google Scholar
Nejadnik, M. R. Google Scholar
Crovace, Murilo Camuri Google Scholar
Zanotto, Edgar Dutra Google Scholar
Wolke, J. G. C. Google Scholar
Jansen, J. A. Google Scholar
van den Beucken, Jeroen J. J. P. Google Scholar
Institution Radboud Univ Nijmegen
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de São Carlos (UFSCar)
Abstract Bioactive glasses (BGs) are known for their unique ability to bond to living bone. Consequently, the incorporation of BGs into calcium phosphate cement (CPC) was hypothesized to be a feasible approach to improve the biological performance of CPC. Previously, it has been demonstrated that BGs can successfully be introduced into CPC, with or without poly(D,L-lactic-co-glycolic) acid (PLGA) microparticles. Although an in vitro physicochemical study on the introduction of BG into CPC was encouraging, the biocompatibility and in vivo bone response to these formulations are still unknown. Therefore, the present study aimed to evaluate the in vivo performance of BG supplemented CPC, either pure or supplemented with PLGA microparticles, via both ectopic and orthotopic implantation models in rats. Pre-set scaffolds in four different formulations (1: CPC; 2: CPC/BG; 3: CPC/PLGA; and 4: CPC/PLGA/BG) were implanted subcutaneously and into femoral condyle defects of rats for 2 and 6 weeks. Upon ectopic implantation, incorporation of BG into CPC improved the soft tissue response by improving capsule and interface quality. Additionally, the incorporation of BG into CPC and CPC/PLGA showed 1.8- and 4.7-fold higher degradation and 2.2- and 1.3-fold higher bone formation in a femoral condyle defect in rats compared to pure CPC and CPC/PLGA, respectively. Consequently, these results highlight the potential of BG to be used as an additive to CPC to improve the biological performance for bone regeneration applications. Nevertheless, further confirmation is necessary regarding long-term in vivo studies, which also have to be performed under compromised wound-healing conditions. (C) 2012 Acta Materialia Inc. Published by Elsevier B.V. All rights reserved.
Keywords Bone substitute
Calcium phosphate cement
Bioactive glass
In vivo
Language English
Sponsor Smart Mix Program of the Netherlands Ministry of Economic Affairs
Netherlands Ministry of Education, Culture and Science
Date 2013-03-01
Published in Acta Biomaterialia. Oxford: Elsevier B.V., v. 9, n. 3, p. 5728-5739, 2013.
ISSN 1742-7061 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 5728-5739
Access rights Closed access
Type Article
Web of Science ID WOS:000315536000033

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