Postprandial interleukin-6 response in elderly with abdominal obesity and metabolic syndrome

Postprandial interleukin-6 response in elderly with abdominal obesity and metabolic syndrome

Author Moreira, P. F. P. Autor UNIFESP Google Scholar
Dalboni, Maria Aparecida Autor UNIFESP Google Scholar
Cendoroglo, M. Autor UNIFESP Google Scholar
Santos, G. M. S. Autor UNIFESP Google Scholar
Cendoroglo, M. S. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The aim of this study is to evaluate the contribution of central obesity to inflammatory responses in the postprandial state in elderly patients with and without metabolic syndrome (MetS).We evaluated 80 elderly individuals who were distributed into three groups: MetS, abdominal obesity (AbObes) and Control, according to ATPIII criteria. Interleukin-6 (IL-6) serum concentration was measured at 0, 2, 4 and 6 hours after the ingestion of a physiological meal without an overload of fat.Serum IL-6 increased 6 hours after the meal in all of the groups (P < 0.001). Comparing the groups, there was no difference in the area under the curve (AUC) of IL-6 in the postprandial state. There was a correlation between the 6-hour changes in the concentrations of IL-6 and the homeostasis model assessment of insulin resistance (HOMA-IR) (r = 0.25, P < 0.05).In this study, differences in abdominal circumference (AC) have not determined a different behavior of IL-6 in the postprandial state, despite the correlation between AC and IL-6. However, we found that, in the elderly, there is a rise in serum IL-6 at 6 hours.
Keywords Aging
inflammation
fat-diet
fatty-acid
HOMA-IR
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2013-03-01
Published in Journal of Nutrition Health & Aging. Paris: Springer France, v. 17, n. 3, p. 206-210, 2013.
ISSN 1279-7707 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 206-210
Origin http://dx.doi.org/10.1007/s12603-012-0400-x
Access rights Closed access
Type Article
Web of Science ID WOS:000316077100001
URI http://repositorio.unifesp.br/handle/11600/36027

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