Transplantation With Kidneys Retrieved From Deceased Donors With Acute Renal Failure

Transplantation With Kidneys Retrieved From Deceased Donors With Acute Renal Failure

Author Klein, Rodrigo Autor UNIFESP Google Scholar
Galante, Nelson Zocoler Autor UNIFESP Google Scholar
Sandes-Freitas, Taina Veras de Autor UNIFESP Google Scholar
Franco, Marcello Fabiano de Autor UNIFESP Google Scholar
Tedesco-Silva, Helio Autor UNIFESP Google Scholar
Medina-Pestana, Jose Osmar Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Hosp Rim & Hipertensao
Abstract Background. the discard rate of kidneys recovered from deceased donors with acute renal failure (ARF) is higher compared with those without ARF mainly due to the uncertainty regarding short-term and long-term outcomes.Methods. We retrospectively analyzed 1-year patient, graft, and rejection-free survivals and renal function of transplantations performed with kidneys recovered from deceased donors with or without ARF, defined as serum creatinine level of more than 1.5 mg/dL. We performed multivariable analysis to evaluate whether ARF was an independent risk factor associated with inferior outcomes.Results. of a total of 1518 patients, 253 received kidneys from expanded-criteria donors (ECD; with ARF [n=116] and without ARF [n=137]) and 1265 from standard-criteria donors (SCD; with ARF [n=369] and without ARF [n=896]). the incidence of delayed graft function was higher in ECD (68.1% vs. 58.4%; P=0.072) and SCD (69.9% vs. 50.6%; P<0.001) recipients of kidneys with ARF compared with those without ARF, respectively. At 1 year, patient, graft, and rejection-free survivals were not statistically different in SCD or ECD recipients with or without ARF. Renal function at 1 year was similar in recipients of ECD (41.9 +/- 26.3 vs. 40.1 +/- 21.7 mL/min; P=0.565) or SCD (50.9 +/- 29.9 vs. 53.6 +/- 28.5 mL/min; P=0.131) kidneys with and without ARF, respectively. Compared with kidneys without ARF, receiving a kidney allograft with ARF was not associated with increased risk of death, graft lost, or inferior renal function 1 year after transplantation.Conclusion. in this cohort of patients, kidneys from deceased donors with ARF provided graft survival and renal function comparable with kidneys from donors without ARF 1 year after transplantation.
Keywords Kidney transplantation
Acute renal failure
Deceased donor
Language English
Sponsor Coordenadoria de Aperfeicoamento de Pessoal de Nivel Superior
Date 2013-02-27
Published in Transplantation. Philadelphia: Lippincott Williams & Wilkins, v. 95, n. 4, p. 611-616, 2013.
ISSN 0041-1337 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 611-616
Origin http://dx.doi.org/10.1097/TP.0b013e318279153c
Access rights Closed access
Type Article
Web of Science ID WOS:000315199200016
URI http://repositorio.unifesp.br/handle/11600/35985

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