Langmuir films containing ibuprofen and phospholipids

Langmuir films containing ibuprofen and phospholipids

Author Geraldo, Vananelia P. N. Google Scholar
Pavinatto, Felippe J. Google Scholar
Nobre, Thatyane M. Google Scholar
Caseli, Luciano Autor UNIFESP Google Scholar
Oliveira, Osvaldo N. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract This study shows the incorporation of ibuprofen, an anti-inflammatory drug, in Langmuir monolayers as cell membrane models. Significant effects were observed for dipalmitoyl phosphatidyl choline (DPPC) monolayers with relevant changes in the elasticity of the monolayer. Dipalmitoyl phosphatidyl glycerol (DPPG) monolayers were affected by small concentrations of ibuprofen, from 1 to 5 mol%. for both types of monolayer, ibuprofen could penetrate into the hydrophobic part of the monolayer, which was confirmed with polarization-modulated infrared reflection-absorption spectroscopy (PM-IRRAS). Brewster angle microscopy (BAM) images showed that ibuprofen prevents the formation of large domains of DPPC. the pharmacological action should occur primarily with penetration of ibuprofen via electrically neutral phospholipid headgroups of the membrane. (c) 2013 Elsevier B.V. All rights reserved.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
rede nBioNet (Brazil)
Date 2013-02-20
Published in Chemical Physics Letters. Amsterdam: Elsevier B.V., v. 559, p. 99-106, 2013.
ISSN 0009-2614 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 99-106
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000314728300018

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