Estimation of percent body fat based on anthropometric measurements in children and adolescents with congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Estimation of percent body fat based on anthropometric measurements in children and adolescents with congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Author Goncalves, Ezequiel M. Google Scholar
Silva, Analiza M. Google Scholar
Matias, Catarina N. Google Scholar
Lemos-Marini, Sofia H. V. Google Scholar
Santos, Allan O. Google Scholar
Guerra-Junior, Gil Google Scholar
Institution Universidade Estadual de Campinas (UNICAMP)
Univ Tecn Lisboa
Universidade Federal de São Paulo (UNIFESP)
Abstract Background & aim: Congenital adrenal hyperplasia due to 21-hydroxylase deficiency is associated with a high risk for obesity. Anthropometric measures are simple and inexpensive methods to assess body fat. However, the accuracy of alternative methods in these patients is unknown. This study aim to develop and evaluate the accuracy of predictive anthropometric equations in the estimation of percent body fat in individuals with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.Methods: A total of 31 female and 22 male patients, aged 7-20 years, were evaluated. Dual-energy X-ray absorptiometry was used as the reference method for body fat, and anthropometric measurements were performed.Results: Three new predictive equations showed similar results: Equation (1) (R-2 = 0.85; SEE = 2.89%), Equation (2) (R-2 = 0.86; SEE = 2.82%), and Equation (3) (R-2 = 0.86; SEE = 2.81%). Internal cross-validation procedures showed a high R-2 (range, 0.84-0.85) and low SEE (<3%). the limits of agreement ranged from -5.6% to 5.6% and no trend was observed.Conclusion: in children and adolescents with congenital adrenal hyperplasia due to 21-hydroxylase deficiency, three new predictive equations were validated for the estimation of percent body fat, with dual-energy X-ray absorptiometry as the reference method. (C) 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
Keywords Anthropometry
Dual X-ray absorptiometry
Body composition
Children
Adolescents
Congenital adrenal hyperplasia
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Ministry of Education, Brazil
Grant number Ministry of Education, Brazil: BEX 2018/10-1
Date 2013-02-01
Published in Clinical Nutrition. Edinburgh: Churchill Livingstone, v. 32, n. 1, p. 45-50, 2013.
ISSN 0261-5614 (Sherpa/Romeo, impact factor)
Publisher Churchill Livingstone
Extent 45-50
Origin http://dx.doi.org/10.1016/j.clnu.2012.05.007
Access rights Closed access
Type Article
Web of Science ID WOS:000315251600006
URI http://repositorio.unifesp.br/handle/11600/35928

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