Low-level laser therapy in different stages of rheumatoid arthritis: a histological study

Low-level laser therapy in different stages of rheumatoid arthritis: a histological study

Author Araruna Alves, Ana Carolina Google Scholar
Camillo de Carvalho, Paulo de Tarso Google Scholar
Parente, Marcio Google Scholar
Xavier, Murilo Google Scholar
Frigo, Lucio Google Scholar
Aimbire, Flavio Autor UNIFESP Google Scholar
Pinto Leal Junior, Ernesto Cesar Google Scholar
Albertini, Regiane Google Scholar
Institution Nove Julho Univ UNINOVE
Univ Camilo Castelo Branco
Vale Jequitinhonha & Mucuri Fed Univ
Univ Cruzeiro Sul
Universidade Federal de São Paulo (UNIFESP)
Abstract Rheumatoid arthritis (RA) is an autoimmune inflammatory disease of unknown etiology. Treatment of RA is very complex, and in the past years, some studies have investigated the use of low-level laser therapy (LLLT) in treatment of RA. However, it remains unknown if LLLT can modulate early and late stages of RA. With this perspective in mind, we evaluated histological aspects of LLLT effects in different RA progression stages in the knee. It was performed a collagen-induced RA model, and 20 male Wistar rats were divided into 4 experimental groups: a non-injured and non-treated control group, a RA non-treated group, a group treated with LLLT (780 nm, 22 mW, 0.10 W/cm(2), spot area of 0.214 cm(2), 7.7 J/cm(2), 75 s, 1.65 J per point, continuous mode) from 12th hour after collagen-induced RA, and a group treated with LLLT from 7th day after RA induction with same LLLT parameters. LLLT treatments were performed once per day. All animals were sacrificed at the 14th day from RA induction and articular tissue was collected in order to perform histological analyses related to inflammatory process. We observed that LLLT both at early and late RA progression stages significantly improved mononuclear inflammatory cells, exudate protein, medullary hemorrhage, hyperemia, necrosis, distribution of fibrocartilage, and chondroblasts and osteoblasts compared to RA group (p < 0.05). We can conclude that LLLT is able to modulate inflammatory response both in early as well as in late progression stages of RA.
Keywords Phototherapy
Rheumatoid arthritis
Language English
Date 2013-02-01
Published in Lasers in Medical Science. London: Springer London Ltd, v. 28, n. 2, p. 529-536, 2013.
ISSN 0268-8921 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 529-536
Origin http://dx.doi.org/10.1007/s10103-012-1102-7
Access rights Closed access
Type Article
Web of Science ID WOS:000315579400024
URI http://repositorio.unifesp.br/handle/11600/35915

Show full item record


File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)




My Account