The combination of atorvastatin and ethanol is not more hepatotoxic to rats than the administration of each drug alone

The combination of atorvastatin and ethanol is not more hepatotoxic to rats than the administration of each drug alone

Author Ito, Daniel Takeshi Autor UNIFESP Google Scholar
Molina, Hercilia Maris Autor UNIFESP Google Scholar
Andriolo, Adagmar Autor UNIFESP Google Scholar
Borges, Durval Rosa Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Animal studies and premarketing clinical trials have revealed hepatotoxicity of statins, primarily minor elevations in serum alanine aminotransferase levels. The combined chronic use of medicines and eventual ethanol abuse are common and may present a synergistic action regarding liver injury. Our objective was to study the effect of the chronic use of atorvastatin associated with acute ethanol administration on the liver in a rat model. One group of rats was treated daily for 5 days a week for 2 months with 0.8 mg/kg atorvastatin by gavage. At the end of the treatment the livers were perfused with 72 mM ethanol for 60 min. Control groups (at least 4 animals in each group) consisted of a group of 2-month-old male Wistar EPM-1 rats exposed to 10% ethanol (v/v) ad libitum replacing water for 2 months, followed by perfusion of the liver with 61 nM atorvastatin for 60 min, and a group of animals without chronic ethanol treatment whose livers were perfused with atorvastatin and/or ethanol. The combination of atorvastatin with ethanol did not increase the release of injury marker enzymes (alanine aminotransferase, aspartate aminotransferase, and lactic dehydrogenase) from the liver and no change in liver function markers (bromosulfophthalein clearance, and oxygen consumption) was observed. Our results suggest that the combination of atorvastatin with ethanol is not more hepatotoxic than the separate use of each substance.
Keywords Atorvastatin
Liver injury
Hepatotoxic
Alcohol
Language English
Date 2007-03-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 3, p. 343-348, 2007.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 343-348
Origin http://dx.doi.org/10.1590/S0100-879X2007000300009
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000244667700009
SciELO ID S0100-879X2007000300009 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/3590

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