A sulfated polysaccharide, fucans, isolated from brown algae Sargassum vulgare with anticoagulant, antithrombotic, antioxidant and anti-inflammatory effects

A sulfated polysaccharide, fucans, isolated from brown algae Sargassum vulgare with anticoagulant, antithrombotic, antioxidant and anti-inflammatory effects

Autor Guerra Dore, Celina Maria P. Google Scholar
Faustino Alves, Monique Gabriela das C. Google Scholar
Pofirio Will, Luiza Sheyla E. Google Scholar
Costa, Thiago G. Google Scholar
Sabry, Diego A. Autor UNIFESP Google Scholar
Souza Rego, Leonardo Augusto R. de Google Scholar
Accardo, Camila de Melo Autor UNIFESP Google Scholar
Rocha, Hugo Alexandre O. . Google Scholar
Filgueira, Luciana Guimaraes A. Google Scholar
Leite, Edda Lisboa Google Scholar
Instituição Univ Fed Rio Grande do Norte
Universidade Federal de São Paulo (UNIFESP)
Resumo Fucan (SV1) sulfated polysaccharides from the brown algae Sargassum vulgare were extracted, fractionated in acetone and examined with respect to chemical composition, anticoagulant, anti-inflammatory, antithrombotic effects and cellular proliferation. These polysaccharides contain low levels of protein, high level of carbohydrate and sulfate. Monosaccharides analysis revealed that SV1 was composed of fucose, galactose, xylose, glucuronic acid and mannose. SV1 polysaccharide prolonged activated partial thromboplastin time (aPTT) and exhibited high antithrombotic action in vivo, with a concentration ten times higher than heparin activity. PSV1, a purified form in gel filtration showed very low biological activities. SV1 stimulated the enzymatic activity of FXa. Its action on DPPH radical scavenging activity was 22%. This polymer has no cytotoxic action (hemolytic) on ABO and Rh blood types in different erythrocyte groups. It displays strong anti-inflammatory action at all concentrations tested in the carrageenan-induced paw edema model, demonstrated by reduced edema and cellular infiltration. (C) 2012 Elsevier B.V. All rights reserved.
Assunto Marine algae
Fucans
Anticoagulant
Antioxidant
Anti-inflamatory
Sargassum vulgare
Idioma Inglês
Financiador Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
MCT
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Data 2013-01-02
Publicado em Carbohydrate Polymers. Oxford: Elsevier B.V., v. 91, n. 1, p. 467-475, 2013.
ISSN 0144-8617 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 467-475
Fonte http://dx.doi.org/10.1016/j.carbpol.2012.07.075
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000310253800060
URI http://repositorio.unifesp.br/handle/11600/35871

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