Granule cell dispersion is not a predictor of surgical outcome in temporal lobe epilepsy with mesial temporal sclerosis

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dc.contributor.author Costa Neves, Rafael Scarpa da [UNIFESP]
dc.contributor.author Jardim, Anaclara Prada [UNIFESP]
dc.contributor.author Caboclo, Luis Otavio [UNIFESP]
dc.contributor.author Lancellotti, Carmen
dc.contributor.author Marinho, Taissa Ferrari [UNIFESP]
dc.contributor.author Hamad, Ana Paula [UNIFESP]
dc.contributor.author Marinho, Murilo [UNIFESP]
dc.contributor.author Centeno, Ricardo [UNIFESP]
dc.contributor.author Cavalheiro, Esper Abrao [UNIFESP]
dc.contributor.author Scorza, Carla Alessandra [UNIFESP]
dc.contributor.author Targas Yacubian, Elza Marcia [UNIFESP]
dc.date.accessioned 2016-01-24T14:31:07Z
dc.date.available 2016-01-24T14:31:07Z
dc.date.issued 2013-01-01
dc.identifier http://dx.doi.org/10.5414/NP300509
dc.identifier.citation Clinical Neuropathology. Deisenhofen-muenchen: Dustri-verlag Dr Karl Feistle, v. 32, n. 1, p. 24-30, 2013.
dc.identifier.issn 0722-5091
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/35870
dc.description.abstract The aim of this retrospective study of a series of patients with mesial temporal lobe epilepsy (MTLE) and mesial temporal sclerosis (MTS) was to analyze the association of granule cell dispersion (GCD) with surgical prognosis, patterns of MTS and clinical data. Hippocampal specimens from 66 patients with MTLE and unilateral MTS and from 13 controls were studied. Quantitative neuropathological evaluation was performed on NeuN-stained hippocampal sections. Patients' clinical data, types of MTS and surgical outcome were reviewed. GCD occurred in 45.5% of cases and was not correlated with clinical variable. More severe neuronal loss was observed in patients with GCD. Except for MTS Type 2 observed only in four no-GCD patients groups did not differ with respect to the types of MTS. Surgical outcome was similar in both groups. in conclusion, GCD was associated with the degree of hippocampal cell loss, but was not a predictor of surgical outcome. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Instituto Nacional de Neurociencia Translacional (INNT), Brazil
dc.format.extent 24-30
dc.language.iso eng
dc.publisher Dustri-verlag Dr Karl Feistle
dc.relation.ispartof Clinical Neuropathology
dc.rights Acesso restrito
dc.subject mesial temporal lobe epilepsy en
dc.subject mesial temporal sclerosis en
dc.subject dentate gyrus en
dc.subject granule cell dispersion en
dc.subject surgical prognosis en
dc.title Granule cell dispersion is not a predictor of surgical outcome in temporal lobe epilepsy with mesial temporal sclerosis en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Santa Casa São Paulo
dc.contributor.institution AFIP
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Neurol & Neurosurg, São Paulo, Brazil
dc.description.affiliation Santa Casa São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliation AFIP, Dept Pathol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Neurol & Neurosci, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Neurol & Neurosurg, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Neurol & Neurosci, São Paulo, Brazil
dc.identifier.doi 10.5414/NP300509
dc.description.source Web of Science
dc.identifier.wos WOS:000314623500005



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