Granule cell dispersion is not a predictor of surgical outcome in temporal lobe epilepsy with mesial temporal sclerosis

Granule cell dispersion is not a predictor of surgical outcome in temporal lobe epilepsy with mesial temporal sclerosis

Author Costa Neves, Rafael Scarpa da Autor UNIFESP Google Scholar
Jardim, Anaclara Prada Autor UNIFESP Google Scholar
Caboclo, Luis Otavio Autor UNIFESP Google Scholar
Lancellotti, Carmen Google Scholar
Marinho, Taissa Ferrari Autor UNIFESP Google Scholar
Hamad, Ana Paula Autor UNIFESP Google Scholar
Marinho, Murilo Autor UNIFESP Google Scholar
Centeno, Ricardo Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrao Autor UNIFESP Google Scholar
Scorza, Carla Alessandra Autor UNIFESP Google Scholar
Targas Yacubian, Elza Marcia Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Santa Casa São Paulo
Abstract The aim of this retrospective study of a series of patients with mesial temporal lobe epilepsy (MTLE) and mesial temporal sclerosis (MTS) was to analyze the association of granule cell dispersion (GCD) with surgical prognosis, patterns of MTS and clinical data. Hippocampal specimens from 66 patients with MTLE and unilateral MTS and from 13 controls were studied. Quantitative neuropathological evaluation was performed on NeuN-stained hippocampal sections. Patients' clinical data, types of MTS and surgical outcome were reviewed. GCD occurred in 45.5% of cases and was not correlated with clinical variable. More severe neuronal loss was observed in patients with GCD. Except for MTS Type 2 observed only in four no-GCD patients groups did not differ with respect to the types of MTS. Surgical outcome was similar in both groups. in conclusion, GCD was associated with the degree of hippocampal cell loss, but was not a predictor of surgical outcome.
Keywords mesial temporal lobe epilepsy
mesial temporal sclerosis
dentate gyrus
granule cell dispersion
surgical prognosis
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Instituto Nacional de Neurociencia Translacional (INNT), Brazil
Date 2013-01-01
Published in Clinical Neuropathology. Deisenhofen-muenchen: Dustri-verlag Dr Karl Feistle, v. 32, n. 1, p. 24-30, 2013.
ISSN 0722-5091 (Sherpa/Romeo, impact factor)
Publisher Dustri-verlag Dr Karl Feistle
Extent 24-30
Access rights Closed access
Type Article
Web of Science ID WOS:000314623500005

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