Adaptive immunity is related to coronary artery disease severity after acute coronary syndrome in subjects with metabolic syndrome

Adaptive immunity is related to coronary artery disease severity after acute coronary syndrome in subjects with metabolic syndrome

Author Izar, Maria C. Autor UNIFESP Google Scholar
Fonseca, Henrique A. Autor UNIFESP Google Scholar
Pinheiro, Luiz F. Autor UNIFESP Google Scholar
Monteiro, Carlos M. Autor UNIFESP Google Scholar
Povoa, Rui M. Autor UNIFESP Google Scholar
Monteiro, Andrea M. Google Scholar
Figueiredo-Neto, Antonio M. Google Scholar
Gidlund, Magnus A. Google Scholar
Fonseca, Francisco A. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Metabolic syndrome (MetS) is an inflammatory state associated with high coronary disease risk. Inflammation and adaptive immunity modulate atherosclerosis and plaque instability. We examined early changes in anti-oxidized low-density lipoprotein (LDL) (anti-oxLDL) autoantibodies (Abs) in patients with MetS after an acute coronary syndrome (ACS). Patients of both genders (n=116) with MetS were prospectively included after an acute myocardial infarction (MI) or hospitalization due to unstable angina. Anti-oxLDL Abs (IgG class) were assayed at baseline, three and six weeks after ACS. the severity of coronary disease was evaluated by the Gensini score. We observed a decrease in anti-oxLDL Abs titers (p<0.002 vs. baseline), mainly in males (p=0.01), in those under 65 y (p=0.03), and in subjects with Gensini score above median (p=0.04). in conclusion, early decrease in circulating anti-oxLDL Abs is associated with coronary disease severity among subjects with MetS.
Keywords Acute coronary syndrome (ACS)
autoantibodies (Abs)
metabolic syndrome (MetS)
oxidized low-density lipoprotein (oxLDL)
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
National Institute of Science and Technology-Nanomaterials for Integrated Markers (INCT-INAMI), Recife, PE, Brazil
Grant number FAPESP: 2004/00325-8
Date 2013-01-01
Published in Diabetes & Vascular Disease Research. London: Sage Publications Ltd, v. 10, n. 1, p. 32-39, 2013.
ISSN 1479-1641 (Sherpa/Romeo, impact factor)
Publisher Sage Publications Ltd
Extent 32-39
Origin http://dx.doi.org/10.1177/1479164112443374
Access rights Closed access
Type Article
Web of Science ID WOS:000314327900005
URI http://repositorio.unifesp.br/handle/11600/35854

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