Correlation analysis of c-myc, p21(WAF/CIP1), p53, C-erbB-2 and COX-2 proteins in esophageal squamous cell carcinoma

Correlation analysis of c-myc, p21(WAF/CIP1), p53, C-erbB-2 and COX-2 proteins in esophageal squamous cell carcinoma

Author Gomes, Thiago Simao Autor UNIFESP Google Scholar
Noguti, Juliana Autor UNIFESP Google Scholar
Forones, Nora Manoukian Autor UNIFESP Google Scholar
Lima, Flavio Oliveira Autor UNIFESP Google Scholar
Dobo, Cristine Autor UNIFESP Google Scholar
Fernandes Junior, Joao Antao Autor UNIFESP Google Scholar
Oshima, Celina Tizuko Fujiyama Autor UNIFESP Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Esophageal cancer is one of the most frequently occurring malignancies and the seventh leading cause of cancer-related deaths in the world. Esophageal squamous cell carcinoma (ESCC) is the most common histological type of esophageal cancer worldwide. Our goal in this study was to detect c-myc, p21(WAF/CIP1), p53, C-erbB-2 and COX-2 immuno-expression in ESCC. Archival formalin-fixed, paraffin-embedded tissues of 18 cases of ESCC (13 biopsies and 5 surgical specimens) were studied, retrospectively, by immunohistochemistry. p53 protein was observed in 50% of the cases, while c-myc was found in 6 of 18 samples (33.33%). All samples (100%) were negative for p21(WAF/CIP1). C-erbB-2 oncoprotein and the COX-2 protein were detected in 5.5% (1/18) and 16.66% (3/18) of the cases, respectively. Taken together, our results suggest that c-myc, p53, C-erbB-2 and COX-2 proteins do not correlate with cancer stage or follow-up in ESCC as revealed by immunohistochemistry. (C) 2012 Elsevier GmbH. All rights reserved.
Keywords Esophageal cancer
Squamous cell carcinoma
Immunohistochemistry
Language English
Date 2013-01-01
Published in Pathology Research and Practice. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 209, n. 1, p. 6-9, 2013.
ISSN 0344-0338 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 6-9
Origin http://dx.doi.org/10.1016/j.prp.2012.08.011
Access rights Closed access
Type Article
Web of Science ID WOS:000315177600002
URI http://repositorio.unifesp.br/handle/11600/35815

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account