Optimizing dentin bond durability: Control of collagen degradation by matrix metalloproteinases and cysteine cathepsins

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dc.contributor.author Tjaderhane, Leo
dc.contributor.author Nascimento, Fabio D.
dc.contributor.author Breschi, Lorenzo
dc.contributor.author Mazzoni, Annalisa
dc.contributor.author Tersariol, Ivarne L. S. [UNIFESP]
dc.contributor.author Geraldeli, Saulo
dc.contributor.author Tezvergil-Mutluay, Arzu
dc.contributor.author Carrilho, Marcela R.
dc.contributor.author Carvalho, Ricardo M.
dc.contributor.author Tay, Franklin R.
dc.contributor.author Pashley, David H.
dc.date.accessioned 2016-01-24T14:31:02Z
dc.date.available 2016-01-24T14:31:02Z
dc.date.issued 2013-01-01
dc.identifier http://dx.doi.org/10.1016/j.dental.2012.08.004
dc.identifier.citation Dental Materials. Oxford: Elsevier B.V., v. 29, n. 1, p. 116-135, 2013.
dc.identifier.issn 0109-5641
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/35800
dc.description.abstract Objectives. Contemporary adhesives lose their bond strength to dentin regardless of the bonding system used. This loss relates to the hydrolysis of collagen matrix of the hybrid layers. the preservation of the collagen matrix integrity is a key issue in the attempts to improve the dentin bonding durability.Methods. Dentin contains collagenolytic enzymes, matrix metalloproteinases (MMPs) and cysteine cathepsins, which are responsible for the hydrolytic degradation of collagen matrix in the bonded interface.Results. the identities, roles and function of collagenolytic enzymes in mineralized dentin has been gathered only within last 15 years, but they have already been demonstrated to have an important role in dental hard tissue pathologies, including the degradation of the hybrid layer. Identifying responsible enzymes facilitates the development of new, more efficient methods to improve the stability of dentin-adhesive bond and durability of bond strength.Significance. Understanding the nature and role of proteolytic degradation of dentin-adhesive interfaces has improved immensely and has practically grown to a scientific field of its own within only 10 years, holding excellent promise that stable resin-dentin bonds will be routinely available in a daily clinical setting already in a near future. (c) 2012 Academy of Dental Materials. Published by Elsevier B.V. All rights reserved. en
dc.description.sponsorship NIDCR
dc.description.sponsorship Academy of Finland
dc.format.extent 116-135
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Dental Materials
dc.rights Acesso restrito
dc.subject Matrix metalloproteinase en
dc.subject Cysteine cathepsin en
dc.subject Dentin en
dc.subject Adhesive en
dc.subject Durability en
dc.subject Collagen en
dc.subject Degradation en
dc.subject Chlorhexidine en
dc.subject Composite resin en
dc.subject Tooth en
dc.title Optimizing dentin bond durability: Control of collagen degradation by matrix metalloproteinases and cysteine cathepsins en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Univ Oulu
dc.contributor.institution Oulu Univ Hosp
dc.contributor.institution Nord Inst Dent Mat NIOM
dc.contributor.institution Univ Bandeirante São Paulo
dc.contributor.institution Univ Trieste
dc.contributor.institution IGM CNR
dc.contributor.institution Rizzoli Orthoped Inst
dc.contributor.institution Univ Mogi das Cruzes
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Florida
dc.contributor.institution Univ Turku
dc.contributor.institution Turku Univ Hosp
dc.contributor.institution Univ Western Ontario
dc.contributor.institution Univ British Columbia
dc.contributor.institution Med Coll Georgia
dc.description.affiliation Univ Oulu, Inst Dent, Oulu 90014, Finland
dc.description.affiliation Oulu Univ Hosp, Oulu, Finland
dc.description.affiliation Nord Inst Dent Mat NIOM, Oslo, Norway
dc.description.affiliation Univ Bandeirante São Paulo, Biomat Res Grp, São Paulo, Brazil
dc.description.affiliation Univ Trieste, Unit Dent Sci & Biomat, Dept Med Sci, I-34127 Trieste, Italy
dc.description.affiliation IGM CNR, Unit Bologna, IOR, Bologna, Italy
dc.description.affiliation Rizzoli Orthoped Inst, Ramses Lab, Lab Immunorheumatol & Tissue Regenerat, Bologna, Italy
dc.description.affiliation Rizzoli Orthoped Inst, Ramses Lab, Cell Biol Lab, Bologna, Italy
dc.description.affiliation Univ Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo UNIFESP, Disciplina Biol Mol, São Paulo, Brazil
dc.description.affiliation Univ Florida, Coll Dent, Restorat Dent Sci Operat Div, Gainesville, FL USA
dc.description.affiliation Univ Turku, Inst Dent, Dept Prosthet Dent, Turku, Finland
dc.description.affiliation Turku Univ Hosp, FIN-20520 Turku, Finland
dc.description.affiliation Univ Western Ontario, London, ON, Canada
dc.description.affiliation Univ British Columbia, Div Biomat, Dept Oral Biol & Med Sci, Vancouver, BC V5Z 1M9, Canada
dc.description.affiliation Med Coll Georgia, Sch Dent, Dept Endodont, Augusta, GA 30912 USA
dc.description.affiliation Med Coll Georgia, Sch Dent, Dept Oral Biol, Augusta, GA 30912 USA
dc.description.affiliationUnifesp Universidade Federal de São Paulo UNIFESP, Disciplina Biol Mol, São Paulo, Brazil
dc.description.sponsorshipID NIDCR: de 015306
dc.identifier.doi 10.1016/j.dental.2012.08.004
dc.description.source Web of Science
dc.identifier.wos WOS:000312269000010



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