HSP27 is Commonly Expressed in Cervical Intraepithelial Lesions of Brazilian Women

HSP27 is Commonly Expressed in Cervical Intraepithelial Lesions of Brazilian Women

Author Dobo, Cristine Autor UNIFESP Google Scholar
Stavale, Joao Norberto Autor UNIFESP Google Scholar
Lima, Flavio de Oliveira Autor UNIFESP Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Arias, Vitor Autor UNIFESP Google Scholar
Gomes, Thiago Simao Autor UNIFESP Google Scholar
Oshima, Celina Tizuko Fujiyama Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Heat shock proteins are molecular chaperones that may be constitutively present in cells protecting them from various stresses, such as extreme temperature, anoxia or chemical agents. Cervical cancer is the second most prevalent malignancy of women. in this study, we analyzed the expression of Hsp27 by immunohistochemistry in cervical intraepithelial lesions of Brazilian women, along with samples from non neoplasic lesions (NN). Cervical intraepithelial neoplasia I (CIN I), II (CIN II) and III (CIN III)/in situ carcinoma and squamous cell carcinoma (SCC) were included. Immunostaining was observed in 30 (100%) samples of NN, 46 (92%) in CIN I, 50 (100%) in CIN II, 52 (98.11%) in CIN III/CIS, and 46 (98.11%) in SCC. in group NN Hsp27 immunostaining was heterogeneous, more intense in basal and parabasal layers of the epithelium and less or absent in the intermediate and superficial layer. the majority of the samples of CIS and SCC presented strong staining in allepithelial layers. Metaplasic cells, when present, were strongly stained. in this study, Hsp27 protein was found to be commonly expressed in cervical epithelial cells.
Keywords HSP27
cervical lesion
immunohistochemistry
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2013-01-01
Published in Asian Pacific Journal of Cancer Prevention. Gyeonggi-do: Asian Pacific Organization Cancer Prevention, v. 14, n. 9, p. 5007-5010, 2013.
ISSN 1513-7368 (Sherpa/Romeo, impact factor)
Publisher Asian Pacific Organization Cancer Prevention
Extent 5007-5010
Origin http://dx.doi.org/10.7314/APJCP.2013.14.9.5007
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000328273000011
URI http://repositorio.unifesp.br/handle/11600/35767

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