Acute inflammatory response to transgastric natural orifice transluminal endoscopic surgery peritoneoscopy: An experimental study in swine

Acute inflammatory response to transgastric natural orifice transluminal endoscopic surgery peritoneoscopy: An experimental study in swine

Autor Rezende, Marcelo Autor UNIFESP Google Scholar
Montero, Edna Frasson de Souza Autor UNIFESP Google Scholar
Salomão, Reinaldo Autor UNIFESP Google Scholar
Brunialti, Milena Autor UNIFESP Google Scholar
Rodrigues, Rodrigo Autor UNIFESP Google Scholar
Gomes, Gustavo Autor UNIFESP Google Scholar
Della Libera, Alice Google Scholar
Ferrari, Angelo Paulo Autor UNIFESP Google Scholar
Della Libera, Ermelindo Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo OBJECTIVE: To investigate the impact of transgastric peritoneal access on plasma biomarkers of acute inflammatory response in comparison to laparoscopy.METHODS: This was a prospective and comparative study in a porcine model. Transgastric peritoneal access performed by natural orifice transluminal endoscopic surgery was compared with laparoscopy. Laparotomy and sham groups were used as positive and negative controls, respectively. Thirty-four pigs were assigned to receive transgastric natural orifice transluminal endoscopic surgery (n = 12), laparoscopy (n = 8), laparotomy (n = 8) or a sham procedure involving only anesthesia (n = 6). in the natural orifice transluminal endoscopic surgery group, peritoneoscopy was performed with a gastroscope via transgastric access. Blood samples were collected at baseline and 1, 3, 6, 9 and 24 h after the surgical procedure for measurement of interleukins 1 beta, 6 and 10 and tumor necrosis factor-alpha. A complete blood count was performed, and C-reactive protein levels were measured at baseline and at 24 h.RESULTS: All surgical and endoscopic procedures were performed without major complications. Peritoneal cavity inventory showed no signs of peritonitis in any animal. Interleukin 1 beta, interleukin 10 and tumor necrosis factor-alpha levels were below the threshold of detection. the mean level of interleukin 6 was statistically significantly higher in the laparotomy group than in the other groups (p < 0.05), with no significant differences among the sham, laparoscopy and natural orifice transluminal endoscopic surgery groups (p > 0.05). C-reactive protein analysis indicated significant increases in all groups, with no differences among the groups. Complete blood count analysis showed no differences among the groups.CONCLUSIONS: Based on the observed interleukin 6 patterns, the systemic inflammatory response resulting from transgastric peritoneal access by natural orifice transluminal endoscopic surgery is similar in intensity to the response that occurs after laparoscopy.
Assunto Natural Orifice Endoscopic Surgery
Laparoscopy
Acute-Phase Reaction
Surgical Procedures
Minimally Invasive
Endoscopy
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Data 2013-01-01
Publicado em Clinics. São Paulo: Hospital Clinicas, Univ São Paulo, v. 68, n. 11, p. 1433-1439, 2013.
ISSN 1807-5932 (Sherpa/Romeo, fator de impacto)
Editor Hospital Clinicas, Univ São Paulo
Extensão 1433-1439
Fonte http://dx.doi.org/10.6061/clinics/2013(11)09
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000329984600009
SciELO S1807-59322013001101433 (estatísticas na SciELO)
URI http://repositorio.unifesp.br/handle/11600/35764

Mostrar registro completo




Arquivos deste item

Nome: S1807-59322013001101433.pdf
Tamanho: 387.7Kb
Formato: PDF
Descrição:
Visualizar/Abrir

Este item aparece na(s) seguinte(s) coleção(s)