Eosinophilic inflammation in allergic asthma

Eosinophilic inflammation in allergic asthma

Author Possa, Samantha S. Google Scholar
Leick, Edna A. Google Scholar
Prado, Carla Maximo Autor UNIFESP Google Scholar
Martins, Milton A. Google Scholar
Tiberio, Iolanda F. L. C. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Eosinophils are circulating granulocytes involved in pathogenesis of asthma. A cascade of processes directed by Th2 cytokine producing T-cells influence the recruitment of eosinophils into the lungs. Furthermore, multiple elements including interleukin (IL)-5, IL-13, chemoattractants such as eotaxin, Clara cells, and CC chemokine receptor (CCR)3 are already directly involved in recruiting eosinophils to the lung during allergic inflammation. Once recruited, eosinophils participate in the modulation of immune response, induction of airway hyperresponsiveness and remodeling, characteristic features of asthma. Various types of promising treatments for reducing asthmatic response are related to reduction in eosinophil counts both in human and experimental models of pulmonary allergic inflammation, showing that the recruitment of these cells really plays an important role in the pathophysiology of allergic diseases such asthma.
Keywords airway remodeling
asthma
eosinophils
experimental models of asthma
inflammation
respiratory hypersensitivity
Language English
Date 2013-01-01
Published in Frontiers in Pharmacology. Lausanne: Frontiers Research Foundation, v. 4, 9 p., 2013.
ISSN 1663-9812 (Sherpa/Romeo, impact factor)
Publisher Frontiers Research Foundation
Extent 9
Origin http://dx.doi.org/10.3389/fphar.2013.00046
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000347011700045
URI http://repositorio.unifesp.br/handle/11600/35738

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