Aberrant DNA methylation of ESR1 and p14ARF genes could be useful as prognostic indicators in osteosarcoma

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dc.contributor.author Sonaglio, Viviane
dc.contributor.author Carvalho, Ana Carolina de [UNIFESP]
dc.contributor.author Toledo, Silvia Regina Caminada de [UNIFESP]
dc.contributor.author Souza, Carolina Salinas de [UNIFESP]
dc.contributor.author Carvalho, Andre L.
dc.contributor.author Petrilli, Antonio Sergio [UNIFESP]
dc.contributor.author Camargo, Beatriz de
dc.contributor.author Vettore, Andre L. [UNIFESP]
dc.date.accessioned 2016-01-24T14:30:56Z
dc.date.available 2016-01-24T14:30:56Z
dc.date.issued 2013-01-01
dc.identifier http://dx.doi.org/10.2147/OTT.S44918
dc.identifier.citation Oncotargets and Therapy. Albany: Dove Medical Press Ltd, v. 6, p. 713-723, 2013.
dc.identifier.issn 1178-6930
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/35733
dc.description.abstract Osteosarcoma (OS) is the eighth most common form of childhood and adolescence cancer. Approximately 10%-20% of patients present metastatic disease at diagnosis and the 5-year overall survival remains around 70% for nonmetastatic patients and around 30% for metastatic patients. Metastatic disease at diagnosis and the necrosis grade induced by preoperative treatment are the only well-established prognostic factors for osteosarcoma. the DNA aberrant methylation is a frequent epigenetic alteration in humans and has been described as a molecular marker in different tumor types. This study evaluated the DNA aberrant methylation status of 18 genes in 34 OS samples without previous chemotherapy treatment and in four normal bone specimens and compared the methylation profile with clinicopathological characteristics of the patients. We were able to define a three-gene panel (AIM1, p14ARF, and ESR1) in which methylation was correlated with OS cases. the hypermethylation of p14ARF showed a significant association with the absence of metastases at diagnoses, while ESR1 hypermethylation was marginally associated with worse overall survival. This study demonstrated that aberrant promoter methylation is a common event in OS and provides evidence that p14ARF and ESR1 hypermethylation could be useful as a prognostic indicator for this disease. en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Fundacao Antonio Prudente (FAP)
dc.format.extent 713-723
dc.language.iso eng
dc.publisher Dove Medical Press Ltd
dc.relation.ispartof Oncotargets and Therapy
dc.rights Acesso aberto
dc.subject DNA methylation en
dc.subject ESR1 en
dc.subject hypermethylation en
dc.subject osteosarcoma en
dc.subject p14ARF en
dc.title Aberrant DNA methylation of ESR1 and p14ARF genes could be useful as prognostic indicators in osteosarcoma en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Barretos Canc Hosp
dc.contributor.institution Inst Nacl Canc
dc.description.affiliation AC Camargo Hosp, Dept Pediat, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Biol Sci, Diadema, Brazil
dc.description.affiliation Universidade Federal de São Paulo, GRAACC, Dept Pediat, Pediat Oncol Inst, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Morphol & Genet, São Paulo, Brazil
dc.description.affiliation Barretos Canc Hosp, Dept Head & Neck Surg, PIO Fdn 12, São Paulo, Brazil
dc.description.affiliation Inst Nacl Canc, Res Program Pediat Oncol Program, CPNq, Rio de Janeiro, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Biol Sci, Diadema, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, GRAACC, Dept Pediat, Pediat Oncol Inst, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Morphol & Genet, São Paulo, Brazil
dc.description.sponsorshipID CNPq: 472193/2004-0
dc.identifier.doi 10.2147/OTT.S44918
dc.description.source Web of Science
dc.identifier.wos WOS:000320437500001



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