Aberrant DNA methylation of ESR1 and p14ARF genes could be useful as prognostic indicators in osteosarcoma

Aberrant DNA methylation of ESR1 and p14ARF genes could be useful as prognostic indicators in osteosarcoma

Author Sonaglio, Viviane Google Scholar
Carvalho, Ana Carolina de Autor UNIFESP Google Scholar
Toledo, Silvia Regina Caminada de Autor UNIFESP Google Scholar
Souza, Carolina Salinas de Autor UNIFESP Google Scholar
Carvalho, Andre L. Google Scholar
Petrilli, Antonio Sergio Autor UNIFESP Google Scholar
Camargo, Beatriz de Google Scholar
Vettore, Andre L. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Barretos Canc Hosp
Inst Nacl Canc
Abstract Osteosarcoma (OS) is the eighth most common form of childhood and adolescence cancer. Approximately 10%-20% of patients present metastatic disease at diagnosis and the 5-year overall survival remains around 70% for nonmetastatic patients and around 30% for metastatic patients. Metastatic disease at diagnosis and the necrosis grade induced by preoperative treatment are the only well-established prognostic factors for osteosarcoma. the DNA aberrant methylation is a frequent epigenetic alteration in humans and has been described as a molecular marker in different tumor types. This study evaluated the DNA aberrant methylation status of 18 genes in 34 OS samples without previous chemotherapy treatment and in four normal bone specimens and compared the methylation profile with clinicopathological characteristics of the patients. We were able to define a three-gene panel (AIM1, p14ARF, and ESR1) in which methylation was correlated with OS cases. the hypermethylation of p14ARF showed a significant association with the absence of metastases at diagnoses, while ESR1 hypermethylation was marginally associated with worse overall survival. This study demonstrated that aberrant promoter methylation is a common event in OS and provides evidence that p14ARF and ESR1 hypermethylation could be useful as a prognostic indicator for this disease.
Keywords DNA methylation
ESR1
hypermethylation
osteosarcoma
p14ARF
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundacao Antonio Prudente (FAP)
Grant number CNPq: 472193/2004-0
Date 2013-01-01
Published in Oncotargets and Therapy. Albany: Dove Medical Press Ltd, v. 6, p. 713-723, 2013.
ISSN 1178-6930 (Sherpa/Romeo, impact factor)
Publisher Dove Medical Press Ltd
Extent 713-723
Origin http://dx.doi.org/10.2147/OTT.S44918
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000320437500001
URI http://repositorio.unifesp.br/handle/11600/35733

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