Pediatric anxiety disorders: from neuroscience to evidence-based clinical practice

Pediatric anxiety disorders: from neuroscience to evidence-based clinical practice

Author Salum, Giovanni Abrahao Google Scholar
DeSousa, Diogo Araujo Google Scholar
Rosario, Maria Conceicao do Autor UNIFESP Google Scholar
Pine, Daniel Samuel Google Scholar
Manfro, Gisele Gus Google Scholar
Institution Univ Fed Rio Grande do Sul
Conselho Nacl Desenvolvimento Cientif & Tecnol CN
Universidade Federal de São Paulo (UNIFESP)
Abstract The objective of this narrative review of the literature is to describe the epidemiology, etiology, pathophysiology, diagnosis, and treatment of pediatric anxiety disorders. We aim to guide clinicians in understanding the biology of anxiety disorders and to provide general guidelines for the proper diagnoses and treatment of these conditions early in life. Anxiety disorders are prevalent, associated with a number of negative life outcomes, and currently under-recognized and under-treated. the etiology involves both genes and environmental influences modifying the neural substrate in a complex interplay. Research on pathophysiology is still in its infancy, but some brain regions, such as the amygdala and the prefrontal cortex, have been implicated in fear and anxiety. Current practice is to establish diagnosis based purely on clinical features, derived from clinical interviews with the child, parents, and teachers. Treatment is effective using medication, cognitive behavioral therapy, or a combination of both. An introduction to the neuroscience behind anxiety disorders combined with an evidence-based approach may help clinicians to understand these disorders and treat them properly in childhood.
Keywords Child
anxiety disorders
obsessive-compulsive disorder
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundo de Incentivo a Pesquisa - Hospital de Clinicas de Porto Alegre - FIPE-HCPA
Date 2013-01-01
Published in Revista Brasileira de Psiquiatria. São Paulo: Assoc Brasileira Psiquiatria, v. 35, p. S3-S21, 2013.
ISSN 1516-4446 (Sherpa/Romeo, impact factor)
Publisher Assoc Brasileira Psiquiatria
Extent S3-S21
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000325742100003
SciELO ID S1516-44462013000500003 (statistics in SciELO)

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