Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country

Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country

Author Velloso, Elvira Deolinda Rodrigues Pereira Google Scholar
Chauffaille, Maria de Lourdes Autor UNIFESP Google Scholar
Pelicario, L. M. Google Scholar
Tanizawa, Roberta Sandra da Silva Google Scholar
Toledo, Silvia Regina Caminada de Autor UNIFESP Google Scholar
Gaiolla, R. D. Google Scholar
Lopes, L. F. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Hosp Canc Barretos
Ctr Tratamento Fabiana Macedo de Morais
Abstract Myelodysplastic syndromes (MDS) and juvenile myelomonocytic leukemia (JMML) are rare hematopoietic stem cell diseases affecting children. Cytogenetics plays an important role in the diagnosis of these diseases. We report here the experience of the Cytogenetic Subcommittee of the Brazilian Cooperative Group on Pediatric Myelodysplastic Syndromes (BCG-MDS-PED). We analyzed 168 cytogenetic studies performed in 23 different cytogenetic centers; 84 of these studies were performed in patients with confirmed MDS (primary MDS, secondary MDS, JMML, and acute myeloid leukemia/MDS+Down syndrome). Clonal abnormalities were found in 36.9% of the MDS cases and cytogenetic studies were important for the detection of constitutional diseases and for differential diagnosis with other myeloid neoplasms. These data show the importance of the Cooperative Group for continuing education in order to avoid a late or wrong diagnosis.
Keywords Childhood myelodysplastic syndromes
Juvenile myelomonocytic leukemia
Cytogenetics
Karyotype
Diagnosis
Language English
Date 2013-01-01
Published in Brazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 46, n. 1, p. 85-90, 2013.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 85-90
Origin http://dx.doi.org/10.1590/1414-431X20122449
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000316126700011
SciELO ID S0100-879X2013000100085 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/35720

Show full item record




File

Name: S0100-879X2013000100085.pdf
Size: 308.9Kb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account