Author |
Velloso, Elvira Deolinda Rodrigues Pereira
![]() Chauffaille, Maria de Lourdes ![]() ![]() Pelicario, L. M. ![]() Tanizawa, Roberta Sandra da Silva ![]() Toledo, Silvia Regina Caminada de ![]() ![]() Gaiolla, R. D. ![]() Lopes, L. F. ![]() |
Institution | Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) Hosp Canc Barretos Ctr Tratamento Fabiana Macedo de Morais |
Abstract | Myelodysplastic syndromes (MDS) and juvenile myelomonocytic leukemia (JMML) are rare hematopoietic stem cell diseases affecting children. Cytogenetics plays an important role in the diagnosis of these diseases. We report here the experience of the Cytogenetic Subcommittee of the Brazilian Cooperative Group on Pediatric Myelodysplastic Syndromes (BCG-MDS-PED). We analyzed 168 cytogenetic studies performed in 23 different cytogenetic centers; 84 of these studies were performed in patients with confirmed MDS (primary MDS, secondary MDS, JMML, and acute myeloid leukemia/MDS+Down syndrome). Clonal abnormalities were found in 36.9% of the MDS cases and cytogenetic studies were important for the detection of constitutional diseases and for differential diagnosis with other myeloid neoplasms. These data show the importance of the Cooperative Group for continuing education in order to avoid a late or wrong diagnosis. |
Keywords |
Childhood myelodysplastic syndromes
Juvenile myelomonocytic leukemia Cytogenetics Karyotype Diagnosis |
Language | English |
Date | 2013-01-01 |
Published in | Brazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 46, n. 1, p. 85-90, 2013. |
ISSN | 0100-879X (Sherpa/Romeo, impact factor) |
Publisher | Assoc Bras Divulg Cientifica |
Extent | 85-90 |
Origin |
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Access rights | Open access ![]() |
Type | Article |
Web of Science ID | WOS:000316126700011 |
SciELO ID | S0100-879X2013000100085 (statistics in SciELO) |
URI | http://repositorio.unifesp.br/handle/11600/35720 |
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