Enhanced Synaptic Connectivity in the Dentate Gyrus during Epileptiform Activity: Network Simulation

Enhanced Synaptic Connectivity in the Dentate Gyrus during Epileptiform Activity: Network Simulation

Author Almeida Franca, Keite Lira de Google Scholar
Guimaraes de Almeida, Antonio-Carlos Google Scholar
Catelli Infantosi, Antonio Fernando Google Scholar
Duarte, Mario Antonio Google Scholar
Silveira, Gilcelio Amaral da Google Scholar
Scorza, Fulvio Alexandre Autor UNIFESP Google Scholar
Arida, Ricardo Mario Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrao Autor UNIFESP Google Scholar
Rodrigues, Antonio Marcio Google Scholar
Institution Universidade Federal de Sergipe (UFS)
Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal de São Paulo (UNIFESP)
Abstract Structural rearrangement of the dentate gyrus has been described as the underlying cause of many types of epilepsies, particularly temporal lobe epilepsy. It is said to occur when aberrant connections are established in the damaged hippocampus, as described in human epilepsy and experimental models. Computer modelling of the dentate gyrus circuitry and the corresponding structural changes has been used to understand how abnormal mossy fibre sprouting can subserve seizure generation observed in experimental models when epileptogenesis is induced by status epilepticus. the model follows the McCulloch-Pitts formalism including the representation of the nonsynaptic mechanisms. the neuronal network comprised granule cells, mossy cells, and interneurons. the compensation theory and the Hebbian and anti-Hebbian rules were used to describe the structural rearrangement including the effects of the nonsynaptic mechanisms on the neuronal activity. the simulations were based on neuroanatomic data and on the connectivity pattern between the cells represented. the results suggest that there is a joint action of the compensation theory and Hebbian rules during the inflammatory process that accompanies the status epilepticus. the structural rearrangement simulated for the dentate gyrus circuitry promotes speculation about the formation of the abnormal mossy fiber sprouting and its role in epileptic seizures.
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2013-01-01
Published in Computational Intelligence and Neuroscience. New York: Hindawi Publishing Corporation, 19 p., 2013.
ISSN 1687-5265 (Sherpa/Romeo, impact factor)
Publisher Hindawi Publishing Corporation
Extent 19
Origin http://dx.doi.org/10.1155/2013/949816
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000334111200001
URI http://repositorio.unifesp.br/handle/11600/35711

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