Exercise and Caloric Restriction Alter the Immune System of Mice Submitted to a High-Fat Diet

Exercise and Caloric Restriction Alter the Immune System of Mice Submitted to a High-Fat Diet

Author Wasinski, Frederick Autor UNIFESP Google Scholar
Bacurau, Reury Frank Pereira Google Scholar
Moraes, Milton R. Autor UNIFESP Google Scholar
Haro, Anderson S. Autor UNIFESP Google Scholar
Moraes-Vieira, Pedro M. M. Google Scholar
Estrela, Gabriel R. Autor UNIFESP Google Scholar
Paredes-Gamero, Edgar J. Autor UNIFESP Google Scholar
Barros, Carlos C. Google Scholar
Almeida, Sandro S. Autor UNIFESP Google Scholar
Camara, Niels O. S. Google Scholar
Araujo, Ronaldo C. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Univ Fed Pelotas
Abstract As the size of adipocytes increases during obesity, the establishment of resident immune cells in adipose tissue becomes an important source of proinflammatory mediators. Exercise and caloric restriction are two important, nonpharmacological tools against body mass increase. To date, their effects on the immune cells of adipose tissue in obese organisms, specifically when a high-fat diet is consumed, have been poorly investigated. Thus, after consuming a high-fat diet, mice were submitted to chronic swimming training or a 30% caloric restriction in order to investigate the effects of both interventions on resident immune cells in adipose tissue. These strategies were able to reduce body mass and resulted in changes in the number of resident immune cells in the adipose tissue and levels of cytokines/chemokines in serum. While exercise increased the number of NK cells in adipose tissue and serum levels of IL-6 and RANTES, caloric restriction increased the CD4+/CD8+ cell ratio and MCP-1 levels. Together, these data demonstrated that exercise and caloric restriction modulate resident immune cells in adipose tissues differently in spite of an equivalent body weight reduction. Additionally, the results also reinforce the idea that a combination of both strategies is better than either individually for combating obesity.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2011/03528-0
Date 2013-01-01
Published in Mediators of Inflammation. New York: Hindawi Publishing Corporation, 8 p., 2013.
ISSN 0962-9351 (Sherpa/Romeo, impact factor)
Publisher Hindawi Publishing Corporation
Extent 8
Origin http://dx.doi.org/10.1155/2013/395672
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000316604200001
URI http://repositorio.unifesp.br/handle/11600/35690

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