Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile

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dc.contributor.author Silva, Narjara Pereira da
dc.contributor.author Suano de Souza, Fabiola Isabel
dc.contributor.author Pendezza, Aline Ifanger
dc.contributor.author Affonso Fonseca, Fernando Luiz
dc.contributor.author Hix, Sonia
dc.contributor.author Oliveira, Allan Chiaratti [UNIFESP]
dc.contributor.author Sarni, Roseli Oselka Saccardo [UNIFESP]
dc.contributor.author D'Almeida, Vania [UNIFESP]
dc.date.accessioned 2016-01-24T14:30:49Z
dc.date.available 2016-01-24T14:30:49Z
dc.date.issued 2013-01-01
dc.identifier http://dx.doi.org/10.1016/j.nut.2012.05.015
dc.identifier.citation Nutrition. New York: Elsevier B.V., v. 29, n. 1, p. 166-171, 2013.
dc.identifier.issn 0899-9007
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/35653
dc.description.abstract Objective: To evaluate homocysteine and total cysteine levels in prepubertal children and to determine the association between these levels and obesity, increased waist circumference, glucose levels, and lipid profile alterations.Methods: Using a cross-sectional study, 677 prepubertal students 6 to 11 y old were assessed. the weight, height, and waist circumference of the students were measured. Laboratory analyses included triacylglycerols, total cholesterol and its fractions, glucose, vitamin B12, folate, homocysteine, and cysteine. Chi-square tests and logistic regression (forward-stepwise) were used for statistical analysis; the significance level was set at 5%.Results: the median age of the students was 8.9 y (6.5-11.5), and the prevalences of overweight and obesity were 90 in 677 (13.3%) and 81 in 677 (12.0%). respectively. An increase in waist circumference was observed in 180 of 677 children (26.6%). Inadequate levels of low-density lipoprotein cholesterol, triacylglycerols, and high-density lipoprotein cholesterol were found in 95 (14.0%), 129 (19.1%), and 179 (26.4%) of the 677 students, respectively. the median homocysteine and total cysteine plasma levels were 5.6 mu mol/L (0.1-11.7) and 365.7 mu mol/L (191.5-589.2), respectively. A multivariate analysis showed that children with a waist circumference above the 90th percentile (7.3 mu mol/L) were 2.4 times (95% confidence interval 1.4-4.0) more likely to have increased homocysteine levels and that children with increased waist circumferences and those with high low-density lipoprotein cholesterol levels were 2.7 (95% confidence interval 1.6-4.6) and 2.1 (95% confidence interval 1.1-4.0) times more likely, respectively, to have total cysteine levels above the 90th percentile (445.0 mu mol/L).Conclusion: the association of abdominal obesity in prepuberty with levels of homocysteine and cysteine found in this study of a prepubertal population could be an early and independent predictor of cardiovascular risk. (C) 2013 Elsevier Inc. All rights reserved. en
dc.format.extent 166-171
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Nutrition
dc.rights Acesso aberto
dc.subject Homocysteine en
dc.subject Cysteine en
dc.subject Waist circumference en
dc.subject Obesity en
dc.subject Children en
dc.title Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Fac Med ABC
dc.description.affiliation Fac Med ABC, Dept Pediat, São Paulo, Brazil
dc.description.affiliation Fac Med ABC, Curso Ciencias Farmaceut, São Paulo, Brazil
dc.description.affiliation Fac Med ABC, Disciplina Bioquim, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Lab Erros Inatos Metab, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Lab Erros Inatos Metab, São Paulo, Brazil
dc.identifier.doi 10.1016/j.nut.2012.05.015
dc.description.source Web of Science
dc.identifier.wos WOS:000313138200027


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