Is early virological response as predictive of the hepatitis C treatment response in dialysis patients as in non-uremic patients?

Is early virological response as predictive of the hepatitis C treatment response in dialysis patients as in non-uremic patients?

Author Pereira, Patrícia da Silva Fucuta Autor UNIFESP Google Scholar
Uehara, Silvia Naomi de Oliveira Autor UNIFESP Google Scholar
Perez, Renata de Mello Autor UNIFESP Google Scholar
Feldner, Ana Cristina de Castro Amaral Autor UNIFESP Google Scholar
Melo, Isaura Cunha de Autor UNIFESP Google Scholar
Souza e Silva, Ivonete Sandra de Autor UNIFESP Google Scholar
Silva, Antonio Eduardo Benedito Autor UNIFESP Google Scholar
Ferraz, Maria Lucia Cardoso Gomes Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: the aim of the present study was to determine whether hepatitis C virus (HCV) RNA present at week 12 is a good predictor of the response to interferon (IFN) monotherapy in hemodialysis patients with hepatitis C.Methods: Hemodialysis patients with hepatitis C who were treated between 1997 and 2008 with IFN monotherapy for 48 weeks without dose reduction were included. the predictive value of HCV RNA at week 12 for achieving a sustained virological response (SVR) was determined.Results: Forty patients (mean age 47 +/- 9 years; 75% males and 80% with genotype 1) were included. Septal fibrosis or cirrhosis was observed in 38% of these patients. Twelve (30%) of the 40 patients achieved SVR. HCV RNA was undetectable at week 12 in 68%. the positive predictive value of HCV RNA at week 12 was 45% and the negative predictive value was 100%.Conclusions: the presence of HCV RNA at week 12 had a high negative predictive value for SVR in hemodialysis patients with chronic hepatitis C treated with IFN for 48 weeks. Therefore, if HCV RNA is detected at week 12, treatment should be discontinued due to the low probability of a sustained response. (0 2012 International Society for Infectious Diseases. Published by Elsevier B.V. All rights reserved.
Keywords Dialysis
Hepatitis C
HCV RNA
Interferon
Predictive value
Language English
Date 2013-01-01
Published in International Journal of Infectious Diseases. Oxford: Elsevier B.V., v. 17, n. 1, p. E50-E53, 2013.
ISSN 1201-9712 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent E50-E53
Origin http://dx.doi.org/10.1016/j.ijid.2012.09.001
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000313560000007
URI http://repositorio.unifesp.br/handle/11600/35646

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