Evaluation of single nucleotide polymorphisms in microRNAs (hsa-miR-196a2 rs11614913 C/T) from Brazilian women with breast cancer

Evaluation of single nucleotide polymorphisms in microRNAs (hsa-miR-196a2 rs11614913 C/T) from Brazilian women with breast cancer

Autor Linhares, Jose Juvenal Autor UNIFESP Google Scholar
Azevedo, Marcos Autor UNIFESP Google Scholar
Siufi, Adalberto Abraao Autor UNIFESP Google Scholar
Carvalho, Cristina Valletta de Autor UNIFESP Google Scholar
Wolgien, Maria Del Carmen Garcia Molina Autor UNIFESP Google Scholar
Noronha, Emmanuelle Coelho Autor UNIFESP Google Scholar
Bonetti, Tatiana Carvalho de Souza Autor UNIFESP Google Scholar
Silva, Ismael Dale Cotrim Guerreiro da Autor UNIFESP Google Scholar
Instituição Univ Fed Ceara
Universidade Federal de São Paulo (UNIFESP)
Ctr Univ Fundacao Santo Andre
Univ S Florida
Resumo Background: Emerging evidence has shown that miRNAs are involved in human carcinogenesis as tumor suppressors or oncogenes. Single nucleotide polymorphisms (SNPs) located in pre-miRNAs may affect the processing and therefore, influence the expression of mature miRNAs. Previous studies generated conflicting results when reporting association between the hsa-miR-196a2 rs11614913 common polymorphism and breast cancer.Methods: This study evaluated the hsa-miR-196a2 rs11614913 SNP in 388 breast cancer cases and 388 controls in Brazilian women. Polymorphism was determined by real-time PCR; control and experimental groups were compared through statistical analysis using the X-2 or Fisher's exact tests.Results: the analysis of the SNPs frequencies showed a significant difference between the groups (BC and CT) in regards to genotype distribution (chi(2): p = 0.024); the homozygous variant (CC) was more frequent in the CT than in the BC group (p = 0.009). the presence of the hsa-miR-196a2 rs11614913 C/T polymorphism was not associated with histological grades (p = 0.522), axillary lymph node positive status (p = 0.805), or clinical stage (p = 0.670) among the breast cancer patients.Conclusions: the results of this study indicated that the CC polymorphic genotype is associated with a decreased risk of BC and the presence of the T allele was significantly associated with an increased risk of BC.
Palavra-chave Breast
Cancer
Polymorphisms
MicroRNAs
Idioma Inglês
Data de publicação 2012-12-10
Publicado em Bmc Medical Genetics. London: Biomed Central Ltd, v. 13, 5 p., 2012.
ISSN 1471-2350 (Sherpa/Romeo, fator de impacto)
Publicador Biomed Central Ltd
Extensão 5
Fonte http://dx.doi.org/10.1186/1471-2350-13-119
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000314816600001
Endereço permanente http://repositorio.unifesp.br/handle/11600/35607

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