Phagocyte-specific S100 proteins and high-sensitivity C reactive protein as biomarkers for a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: a comparative study

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dc.contributor.author Gerss, Joachim
dc.contributor.author Roth, Johannes
dc.contributor.author Holzinger, Dirk
dc.contributor.author Ruperto, Nicolino
dc.contributor.author Wittkowski, Helmut
dc.contributor.author Frosch, Michael
dc.contributor.author Wulffraat, Nico
dc.contributor.author Wedderburn, Lucy
dc.contributor.author Stanevicha, Valda
dc.contributor.author Mihaylova, Dimitrina
dc.contributor.author Harjacek, Miroslav
dc.contributor.author Len, Claudio Arnaldo [UNIFESP]
dc.contributor.author Toppino, Claudia
dc.contributor.author Masi, Massimo
dc.contributor.author Minden, Kirsten
dc.contributor.author Saurenmann, Traudel
dc.contributor.author Uziel, Yosef
dc.contributor.author Vesely, Richard
dc.contributor.author Teresa Apaz, Maria
dc.contributor.author Kuester, Rolf-Michael
dc.contributor.author Rua Elorduy, Maria Jesus
dc.contributor.author Burgos-Vargas, Ruben
dc.contributor.author Ioseliani, Maka
dc.contributor.author Magni-Manzoni, Silvia
dc.contributor.author Unsal, Erbil
dc.contributor.author Anton, Jordi
dc.contributor.author Balogh, Zsolt
dc.contributor.author Hagelberg, Stefan
dc.contributor.author Mazur-Zielinska, Henryka
dc.contributor.author Tauber, Tsivia
dc.contributor.author Martini, Alberto
dc.contributor.author Foell, Dirk
dc.contributor.author Paediat Rheumatology Int Trials
dc.date.accessioned 2016-01-24T14:28:08Z
dc.date.available 2016-01-24T14:28:08Z
dc.date.issued 2012-12-01
dc.identifier http://dx.doi.org/10.1136/annrheumdis-2012-201329
dc.identifier.citation Annals of the Rheumatic Diseases. London: Bmj Publishing Group, v. 71, n. 12, p. 1991-1997, 2012.
dc.identifier.issn 0003-4967
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/35595
dc.description.abstract Objectives Juvenile idiopathic arthritis (JIA) is a chronic inflammatory joint disease affecting children. Even if remission is successfully induced, about half of the patients experience a relapse after stopping anti-inflammatory therapy. the present study investigated whether patients with JIA at risk of relapse can be identified by biomarkers even if clinical signs of disease activity are absent.Methods Patients fulfilling the criteria of inactive disease on medication were included at the time when all medication was withdrawn. the phagocyte activation markers S100A12 and myeloid-related proteins 8/14 (MRP8/14) were compared as well as the acute phase reactant high-sensitivity C reactive protein (hsCRP) as predictive biomarkers for the risk of a flare within a time frame of 6 months.Results 35 of 188 enrolled patients experienced a flare within 6 months. Clinical or standard laboratory parameters could not differentiate between patients at risk of relapse and those not at risk. S100A12 and MRP8/14 levels were significantly higher in patients who subsequently developed flares than in patients with stable remission. the best single biomarker for the prediction of flare was S100A12 (HR 2.81). the predictive performance may be improved if a combination with hsCRP is used.Conclusions Subclinical disease activity may result in unstable remission (ie, a status of clinical but not immunological remission). Biomarkers such as S100A12 and MRP8/14 inform about the activation status of innate immunity at the molecular level and thereby identify patients with unstable remission and an increased risk of relapse. en
dc.description.sponsorship Interdisciplinary Centre of Clinical Research at the University of Muenster
dc.description.sponsorship FP7-Network PHARMACHILD
dc.description.sponsorship PRINTO
dc.format.extent 1991-1997
dc.language.iso eng
dc.publisher Bmj Publishing Group
dc.relation.ispartof Annals of the Rheumatic Diseases
dc.rights Acesso restrito
dc.title Phagocyte-specific S100 proteins and high-sensitivity C reactive protein as biomarkers for a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: a comparative study en
dc.type Artigo
dc.contributor.institution Univ Munster
dc.contributor.institution Univ Childrens Hosp Muenster
dc.contributor.institution PRINTO
dc.contributor.institution Wilhelmina Childrens Hosp
dc.contributor.institution Inst Child Hlth UCL
dc.contributor.institution Riga Stradins Univ
dc.contributor.institution Univ Children Hosp
dc.contributor.institution Childrens Hosp Zagreb
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Turin
dc.contributor.institution Univ Bologna
dc.contributor.institution Charite
dc.contributor.institution Univ Childrens Hosp
dc.contributor.institution Meir Med Ctr
dc.contributor.institution Detska Fakultna Nemocn
dc.contributor.institution Univ Catolica
dc.contributor.institution N Deutsch Zentrum Kinder & Jugendrheumatol
dc.contributor.institution Hosp Cruces
dc.contributor.institution Hosp Gen Mexico City
dc.contributor.institution M Iashvili Childrens Cent Clin
dc.contributor.institution SC Pediat Osped
dc.contributor.institution Dokuz Eylul Univ
dc.contributor.institution Hosp St Joan de Deu
dc.contributor.institution Natl Inst Rheumatol & Physiotherapy ORFI
dc.contributor.institution Karolinska Univ Hosp
dc.contributor.institution Med Univ Silesia
dc.contributor.institution Asaf Harofe Med Ctr
dc.contributor.institution Univ Genoa
dc.description.affiliation Univ Munster, Inst Immunol, D-48149 Munster, Germany
dc.description.affiliation Univ Munster, Inst Biostat & Clin Res, D-48149 Munster, Germany
dc.description.affiliation Univ Munster, Interdisciplinary Ctr Clin Res, D-48149 Munster, Germany
dc.description.affiliation Univ Childrens Hosp Muenster, Dept Gen Pediat, Munster, Germany
dc.description.affiliation PRINTO, IRCCS G Gaslini, Genoa, Italy
dc.description.affiliation Wilhelmina Childrens Hosp, Dept Paediat Immunol & Rheumatol, Utrecht, Netherlands
dc.description.affiliation Inst Child Hlth UCL, Rheumatol Unit, London, England
dc.description.affiliation Riga Stradins Univ, Riga, Latvia
dc.description.affiliation Univ Children Hosp, Dept Paediat Rheumatol, Sofia, Bulgaria
dc.description.affiliation Childrens Hosp Zagreb, Dept Pediat, Zagreb, Croatia
dc.description.affiliation Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliation Univ Turin, Pediat Clin, Dipartimento Sci Pediat & Adolescenza, Turin, Italy
dc.description.affiliation Univ Bologna, Policlin S Orsola Malpighi, Pediat Clin, Bologna, Italy
dc.description.affiliation Charite, Kinderklin, Berlin, Germany
dc.description.affiliation Univ Childrens Hosp, Zurich, Switzerland
dc.description.affiliation Meir Med Ctr, Dept Pediat, Kefar Sava, Israel
dc.description.affiliation Detska Fakultna Nemocn, Dept Pediat 1, Kosice, Slovakia
dc.description.affiliation Univ Catolica, Clin Reina Fabiola, GESER Rheumatol, Cordoba, Argentina
dc.description.affiliation N Deutsch Zentrum Kinder & Jugendrheumatol, Rheumaklin Bad Bramstedt, Bad Bramstedt, Germany
dc.description.affiliation Hosp Cruces, Unidad Reumatol Pediat, Bilbao Vizcaya, Spain
dc.description.affiliation Hosp Gen Mexico City, Serv Reumatol, Mexico City, DF, Mexico
dc.description.affiliation M Iashvili Childrens Cent Clin, Div Rheumatol, Tbilisi, Rep of Georgia
dc.description.affiliation SC Pediat Osped, Fdn IRCCS Policlin S Matteo, Pavia, Italy
dc.description.affiliation Dokuz Eylul Univ, Fac Med, Div Pediat Rheumatol Immunol, Izmir, Turkey
dc.description.affiliation Hosp St Joan de Deu, Unidad Reumatol Pediat, Esplugues, Barcelona, Spain
dc.description.affiliation Natl Inst Rheumatol & Physiotherapy ORFI, Gen & Pediat Rheumatol Dept 3, Budapest, Hungary
dc.description.affiliation Karolinska Univ Hosp, Pediat Rheumatol Unit, Stockholm, Sweden
dc.description.affiliation Med Univ Silesia, Dept Pediat, Zabrze, Poland
dc.description.affiliation Asaf Harofe Med Ctr, Pediat Rheumatol Clin, Zerifin, Israel
dc.description.affiliation Univ Genoa, Dipartimento Pediat, Genoa, Italy
dc.description.affiliationUnifesp Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.sponsorshipID Interdisciplinary Centre of Clinical Research at the University of Muenster: IZKF CRA04
dc.identifier.doi 10.1136/annrheumdis-2012-201329
dc.description.source Web of Science
dc.identifier.wos WOS:000310701300016



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