Phagocyte-specific S100 proteins and high-sensitivity C reactive protein as biomarkers for a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: a comparative study

Phagocyte-specific S100 proteins and high-sensitivity C reactive protein as biomarkers for a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: a comparative study

Author Gerss, Joachim Google Scholar
Roth, Johannes Google Scholar
Holzinger, Dirk Google Scholar
Ruperto, Nicolino Google Scholar
Wittkowski, Helmut Google Scholar
Frosch, Michael Google Scholar
Wulffraat, Nico Google Scholar
Wedderburn, Lucy Google Scholar
Stanevicha, Valda Google Scholar
Mihaylova, Dimitrina Google Scholar
Harjacek, Miroslav Google Scholar
Len, Claudio Arnaldo Autor UNIFESP Google Scholar
Toppino, Claudia Google Scholar
Masi, Massimo Google Scholar
Minden, Kirsten Google Scholar
Saurenmann, Traudel Google Scholar
Uziel, Yosef Google Scholar
Vesely, Richard Google Scholar
Teresa Apaz, Maria Google Scholar
Kuester, Rolf-Michael Google Scholar
Rua Elorduy, Maria Jesus Google Scholar
Burgos-Vargas, Ruben Google Scholar
Ioseliani, Maka Google Scholar
Magni-Manzoni, Silvia Google Scholar
Unsal, Erbil Google Scholar
Anton, Jordi Google Scholar
Balogh, Zsolt Google Scholar
Hagelberg, Stefan Google Scholar
Mazur-Zielinska, Henryka Google Scholar
Tauber, Tsivia Google Scholar
Martini, Alberto Google Scholar
Foell, Dirk Google Scholar
Paediat Rheumatology Int Trials Google Scholar
Institution Univ Munster
Univ Childrens Hosp Muenster
PRINTO
Wilhelmina Childrens Hosp
Inst Child Hlth UCL
Riga Stradins Univ
Univ Children Hosp
Childrens Hosp Zagreb
Universidade Federal de São Paulo (UNIFESP)
Univ Turin
Univ Bologna
Charite
Univ Childrens Hosp
Meir Med Ctr
Detska Fakultna Nemocn
Univ Catolica
N Deutsch Zentrum Kinder & Jugendrheumatol
Hosp Cruces
Hosp Gen Mexico City
M Iashvili Childrens Cent Clin
SC Pediat Osped
Dokuz Eylul Univ
Hosp St Joan de Deu
Natl Inst Rheumatol & Physiotherapy ORFI
Karolinska Univ Hosp
Med Univ Silesia
Asaf Harofe Med Ctr
Univ Genoa
Abstract Objectives Juvenile idiopathic arthritis (JIA) is a chronic inflammatory joint disease affecting children. Even if remission is successfully induced, about half of the patients experience a relapse after stopping anti-inflammatory therapy. the present study investigated whether patients with JIA at risk of relapse can be identified by biomarkers even if clinical signs of disease activity are absent.Methods Patients fulfilling the criteria of inactive disease on medication were included at the time when all medication was withdrawn. the phagocyte activation markers S100A12 and myeloid-related proteins 8/14 (MRP8/14) were compared as well as the acute phase reactant high-sensitivity C reactive protein (hsCRP) as predictive biomarkers for the risk of a flare within a time frame of 6 months.Results 35 of 188 enrolled patients experienced a flare within 6 months. Clinical or standard laboratory parameters could not differentiate between patients at risk of relapse and those not at risk. S100A12 and MRP8/14 levels were significantly higher in patients who subsequently developed flares than in patients with stable remission. the best single biomarker for the prediction of flare was S100A12 (HR 2.81). the predictive performance may be improved if a combination with hsCRP is used.Conclusions Subclinical disease activity may result in unstable remission (ie, a status of clinical but not immunological remission). Biomarkers such as S100A12 and MRP8/14 inform about the activation status of innate immunity at the molecular level and thereby identify patients with unstable remission and an increased risk of relapse.
Language English
Sponsor Interdisciplinary Centre of Clinical Research at the University of Muenster
FP7-Network PHARMACHILD
PRINTO
Grant number Interdisciplinary Centre of Clinical Research at the University of Muenster: IZKF CRA04
Date 2012-12-01
Published in Annals of the Rheumatic Diseases. London: Bmj Publishing Group, v. 71, n. 12, p. 1991-1997, 2012.
ISSN 0003-4967 (Sherpa/Romeo, impact factor)
Publisher Bmj Publishing Group
Extent 1991-1997
Origin http://dx.doi.org/10.1136/annrheumdis-2012-201329
Access rights Closed access
Type Article
Web of Science ID WOS:000310701300016
URI http://repositorio.unifesp.br/handle/11600/35595

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