Vesicles as carriers of virulence factors in parasitic protozoan diseases

Vesicles as carriers of virulence factors in parasitic protozoan diseases

Author Torrecilhas, Ana Claudia Autor UNIFESP Google Scholar
Schumacher, Robert I. Google Scholar
Alves, Maria Julia M. Google Scholar
Colli, Walter Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Different types of shed vesicles as, for example, exosomes, plasma-membrane-derived vesicles or microparticles, are the focus of intense research in view of their potential role in cell cell communication and under the perspective that they might be good tools for immunotherapy, vaccination or diagnostic purposes. This review discusses ways employed by pathogenic trypanosomatids to interact with the host by shedding vesicles that contain molecules important for the establishment of infection, as opposed to previous beliefs considering them as a waste of cellular metabolism. Trypanosomatids are compared with Apicomplexa, which circulate parasite antigens bound to vesicles shed by host cells. the knowledge of the origin and chemical composition of these different vesicles might lead to the understanding of the mechanisms that determine their biological function. (C) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
Keywords Pathogenic protozoan parasites
Virulence factors
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2012-12-01
Published in Microbes and Infection. Amsterdam: Elsevier B.V., v. 14, n. 15, p. 1465-1474, 2012.
ISSN 1286-4579 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1465-1474
Access rights Closed access
Type Article
Web of Science ID WOS:000313151600011

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