RARS with fibrosis and del(20q) transformed into ALL

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dc.contributor.author Rohr, Sandra S. [UNIFESP]
dc.contributor.author Flores Pelloso, Luis Arthur [UNIFESP]
dc.contributor.author Borgo, Aline dos Santos [UNIFESP]
dc.contributor.author Rezende, Joao Garibaldi de [UNIFESP]
dc.contributor.author Regis Silva, Maria Regina [UNIFESP]
dc.contributor.author Yamamoto, Mihoko [UNIFESP]
dc.contributor.author Chauffaille, Maria de Lourdes L. F. [UNIFESP]
dc.date.accessioned 2016-01-24T14:28:04Z
dc.date.available 2016-01-24T14:28:04Z
dc.date.issued 2012-12-01
dc.identifier http://dx.doi.org/10.1007/s12032-012-0297-6
dc.identifier.citation Medical Oncology. Totowa: Humana Press Inc, v. 29, n. 5, p. 3570-3573, 2012.
dc.identifier.issn 1357-0560
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/35549
dc.description.abstract Transformation of myelodysplastic syndrome (MDS) into acute myelogenous leukemia occurs in approximately 30 % of cases, while progression into acute lymphoblastic leukemia (ALL) is rare. We report on a 67-year-old man with the diagnosis of MDS, subtype refractory anemia with ring sideroblasts (RARS), karyotype 20q- , JAK-2 negative and grade III fibrosis on the bone marrow biopsy, who evolved into ALL 33 months after the diagnosis of MDS. RARS is one of the subtypes of MDS with most indolent course. Deletion of the long arm of chromosome 20 (20q-) is considered as good prognosis by the International Prognostic Scoring System, an important scoring system for predicting survival and evolution of MDS. Primary MDS with bone marrow fibrosis may represent a distinct clinicopathological and is supposed to have an unfavorable prognosis. the combined analysis of these features makes this rare report still more challenging and illustrates that biology of MDS is yet to be discovered. en
dc.format.extent 3570-3573
dc.language.iso eng
dc.publisher Humana Press Inc
dc.relation.ispartof Medical Oncology
dc.rights Acesso restrito
dc.subject MDS with fibrosis en
dc.subject RARS en
dc.subject MDS transformation en
dc.subject Secondary ALL en
dc.subject del(20q) en
dc.title RARS with fibrosis and del(20q) transformed into ALL en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Disciplina Hematol & Hemoterapia, UNIFESP Escola Paulista Med, BR-04023900 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Disciplina Patol Invest, UNIFESP Escola Paulista Med, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Disciplina Hematol & Hemoterapia, UNIFESP Escola Paulista Med, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Disciplina Patol Invest, UNIFESP Escola Paulista Med, BR-04023900 São Paulo, Brazil
dc.identifier.doi 10.1007/s12032-012-0297-6
dc.description.source Web of Science
dc.identifier.wos WOS:000311513800082



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