RARS with fibrosis and del(20q) transformed into ALL

RARS with fibrosis and del(20q) transformed into ALL

Author Rohr, Sandra S. Autor UNIFESP Google Scholar
Flores Pelloso, Luis Arthur Autor UNIFESP Google Scholar
Borgo, Aline dos Santos Autor UNIFESP Google Scholar
Rezende, Joao Garibaldi de Autor UNIFESP Google Scholar
Regis Silva, Maria Regina Autor UNIFESP Google Scholar
Yamamoto, Mihoko Autor UNIFESP Google Scholar
Chauffaille, Maria de Lourdes L. F. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Transformation of myelodysplastic syndrome (MDS) into acute myelogenous leukemia occurs in approximately 30 % of cases, while progression into acute lymphoblastic leukemia (ALL) is rare. We report on a 67-year-old man with the diagnosis of MDS, subtype refractory anemia with ring sideroblasts (RARS), karyotype 20q- , JAK-2 negative and grade III fibrosis on the bone marrow biopsy, who evolved into ALL 33 months after the diagnosis of MDS. RARS is one of the subtypes of MDS with most indolent course. Deletion of the long arm of chromosome 20 (20q-) is considered as good prognosis by the International Prognostic Scoring System, an important scoring system for predicting survival and evolution of MDS. Primary MDS with bone marrow fibrosis may represent a distinct clinicopathological and is supposed to have an unfavorable prognosis. the combined analysis of these features makes this rare report still more challenging and illustrates that biology of MDS is yet to be discovered.
Keywords MDS with fibrosis
MDS transformation
Secondary ALL
Language English
Date 2012-12-01
Published in Medical Oncology. Totowa: Humana Press Inc, v. 29, n. 5, p. 3570-3573, 2012.
ISSN 1357-0560 (Sherpa/Romeo, impact factor)
Publisher Humana Press Inc
Extent 3570-3573
Origin http://dx.doi.org/10.1007/s12032-012-0297-6
Access rights Closed access
Type Article
Web of Science ID WOS:000311513800082
URI http://repositorio.unifesp.br/handle/11600/35549

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