Acute promyelocytic leukemia associated with the PLZF-RARA fusion gene: two additional cases with clinical and laboratorial peculiar presentations

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dc.contributor.author Rohr, Sandra S. [UNIFESP]
dc.contributor.author Flores Pelloso, Luis Arthur [UNIFESP]
dc.contributor.author Borgo, Aline [UNIFESP]
dc.contributor.author De Nadai, Livia Chiosini [UNIFESP]
dc.contributor.author Yamamoto, Mihoko [UNIFESP]
dc.contributor.author Rego, Eduardo M.
dc.contributor.author Chauffaille, Maria de Lourdes L. F. [UNIFESP]
dc.date.accessioned 2016-01-24T14:28:04Z
dc.date.available 2016-01-24T14:28:04Z
dc.date.issued 2012-12-01
dc.identifier http://dx.doi.org/10.1007/s12032-011-0147-y
dc.identifier.citation Medical Oncology. Totowa: Humana Press Inc, v. 29, n. 4, p. 2345-2347, 2012.
dc.identifier.issn 1357-0560
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/35547
dc.description.abstract Acute promyelocytic leukemia (APL) is characterized by the presence of the t(15;17) and PML-RARa rearrangement, with good response to treatment with retinoids. However, few cases of variant APL involving alternative chromosomal aberrations have been reported, including t(11;17)(q23;q21) (Wells et al. in Nat Genet 17:109-113, 1; Arnould et al. in Hum Mol Genet 8:1741-1749, 2) t(5;17)(q35;q12-21), t(11;17)(q13;q21) (Grimwade et al in Blood 96:1297-1308, 3) and der(17) (Rego et al. in Blood (ASH Annual Meeting Abstracts)114:Abstract 6, 4), whereby RARa is fused to the PLZF, NPM, NuMA, and STAT5b genes, respectively, have been described. These cases are characterized by distinct morphology, clinical presentation, and in respect to PLZF, a lack of differentiation response to retinoids leading to the need of different approaches concerning diagnostic methods and therapeutics. This paper describes two cases of APL associated with the PLZF-RARA fusion gene enrolled in the IC-APL trial that is a non-randomized, multicenter study conducted in Brazil, Mexico, Chile and Uruguay with the aim to improve the treatment outcome of APL patients in developing countries. These cases, although rare, offer a challenge to its early recognition and proper conduction. en
dc.format.extent 2345-2347
dc.language.iso eng
dc.publisher Humana Press Inc
dc.relation.ispartof Medical Oncology
dc.rights Acesso restrito
dc.subject Acute promyelocytic leukemia en
dc.subject PLZF-RARA en
dc.subject t(11;17) en
dc.subject Molecular rearrangement en
dc.subject Promyelocytic variant translocation en
dc.title Acute promyelocytic leukemia associated with the PLZF-RARA fusion gene: two additional cases with clinical and laboratorial peculiar presentations en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Universidade Federal de São Paulo, Disciplina Hematol & Hemoterapia, UNIFESP, Escola Paulista Med, BR-04023900 São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Fac Med Ribeirao Preto, Dept Hematol, Ribeirao Preto, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Disciplina Hematol & Hemoterapia, UNIFESP, Escola Paulista Med, BR-04023900 São Paulo, Brazil
dc.identifier.doi 10.1007/s12032-011-0147-y
dc.description.source Web of Science
dc.identifier.wos WOS:000309711600006



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