Methane production and small intestinal bacterial overgrowth in children living in a slum

Methane production and small intestinal bacterial overgrowth in children living in a slum

Author Mello, Carolina Santos Autor UNIFESP Google Scholar
Tahan, Soraia Autor UNIFESP Google Scholar
Melli, Lígia Cristina Fonseca Lahoz Autor UNIFESP Google Scholar
Rodrigues, Mirian Silva do Carmo Autor UNIFESP Google Scholar
Mello, Ricardo Martin Pereira de Autor UNIFESP Google Scholar
Scaletsky, Isabel Cristina Affonso Autor UNIFESP Google Scholar
Morais, Mauro Batista de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Ctr Fdn Inst Educ Osasco
Abstract AIM: To analyze small intestinal bacterial overgrowth in school-aged children and the relationship between hydrogen and methane production in breath tests.METHODS: This transversal study included 85 children residing in a slum and 43 children from a private school, all aged between 6 and 10 years, in Osasco, Brazil. for characterization of the groups, data regarding the socioeconomic status and basic housing sanitary conditions were collected. Anthropometric data was obtained in children from both groups. All children completed the hydrogen (H-2) and methane (CH4) breath test in order to assess small intestinal bacterial overgrowth (SIBO). SIBO was diagnosed when there was an increase in H-2 >= 20 ppm or CH4 >= 10 ppm with regard to the fasting value until 60 min after lactulose ingestion.RESULTS: Children from the slum group had worse living conditions and lower nutritional indices than children from the private school. SIBO was found in 30.9% (26/84) of the children from the slum group and in 2.4% (1/41) from the private school group (P = 0.0007). Greater hydrogen production in the small intestine was observed in children from the slum group when compared to children from the private school (P = 0.007). A higher concentration of hydrogen in the small intestine (P < 0.001) and in the colon (P < 0.001) was observed among the children from the slum group with SIBO when compared to children from the slum group without SIBO. Methane production was observed in 63.1% (53/84) of the children from the slum group and in 19.5% (8/41) of the children from the private school group (P < 0.0001). Methane production was observed in 38/58 (65.5%) of the children without SIBO and in 15/26 (57.7%) of the children with SIBO from the slum. Colonic production of hydrogen was lower in methane-producing children (P = 0.017).CONCLUSION: Children who live in inadequate environmental conditions are at risk of bacterial overgrowth and methane production. Hydrogen is a substrate for methane production in the colon. (C) 2012 Baishideng. All rights reserved.
Keywords Bacterial overgrowth
Breath test
Children
Colon
Hydrogen
Methane
Small intestine
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Food and Nutrition Fund-Municipal Health Fund of Osasco, São Paulo, Brazil
Date 2012-11-07
Published in World Journal of Gastroenterology. Beijing: Baishideng Publ Grp Co Ltd, v. 18, n. 41, p. 5932-5939, 2012.
ISSN 1007-9327 (Sherpa/Romeo, impact factor)
Publisher Baishideng Publ Grp Co Ltd
Extent 5932-5939
Origin http://dx.doi.org/10.3748/wjg.v18.i41.5932
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000311195200013
URI http://repositorio.unifesp.br/handle/11600/35503

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