Histological evolution of hepatitis C virus infection after renal transplantation

Histological evolution of hepatitis C virus infection after renal transplantation

Author Oliveira Uehara, Silvia Naomi de Autor UNIFESP Google Scholar
Emori, Christini Takemi Autor UNIFESP Google Scholar
Pereira, Patrícia da Silva Fucuta Autor UNIFESP Google Scholar
Perez, Renata M. Google Scholar
Medina Pestana, Jose Osmar Google Scholar
Lanzoni, Valeria Pereira Google Scholar
Souza e Silva, Ivonete Sandra Autor UNIFESP Google Scholar
Benedito Silva, Antonio Eduardo Autor UNIFESP Google Scholar
Ferraz, Maria Lucia Cardoso Gomes Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio de Janeiro (UFRJ)
Abstract Background: information regarding histological progression of hepatitis C after renal transplant (RTx) is scarce. Aims: To analyze clinical and laboratory evolution and histological progression of hepatitis C in patients evaluated before and after RTx.Methods: Twenty-two HCV-infected patients submitted to liver biopsy pre- and post-RTx were included. A semiquantitative analysis of necroinflammatory activity and fibrosis staging was performed and the two biopsies were compared.Results: Patients were mostly men (73%) with mean age of 36 +/- 9 yr. Time post-transplant was 4 +/- 2 yr and time between biopsies was 5 +/- 2 yr. An elevation of alanine aminotransferase (p = 0.041) and aspartate aminotransferase (p = 0.004) levels was observed in the post-transplant period. Fibrosis progression after renal transplantation was observed in 11 (50%) of the patients, and necroinflammatory activity worsening was observed in 7 (32%) of the patients. the histological progression occurred even among those without significant histological lesions in pre-transplant biopsy.Conclusion: the findings of this study suggest that the practice of indicating treatment in the pre-transplant phase based mainly on histological disease should be revised, because a high proportion of patients present disease progression. Because interferon cannot be used safely after RTx, treatment should be indicated for all ESRD patients with hepatitis C.
Keywords chronic kidney failure
hepatitis C
kidney transplantation
liver disease
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2012-11-01
Published in Clinical Transplantation. Hoboken: Wiley-Blackwell, v. 26, n. 6, p. 842-848, 2012.
ISSN 0902-0063 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 842-848
Origin http://dx.doi.org/10.1111/j.1399-0012.2012.01635.x
Access rights Closed access
Type Article
Web of Science ID WOS:000312129100015
URI http://repositorio.unifesp.br/handle/11600/35484

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