Molecular phylogeny and phenotypic variability of clinical and environmental strains of Aspergillus flavus

Molecular phylogeny and phenotypic variability of clinical and environmental strains of Aspergillus flavus

Author Goncalves, Sarah S. Autor UNIFESP Google Scholar
Cano, Josep F. Google Scholar
Stchigel, Alberto M. Google Scholar
Melo, Analy S. Autor UNIFESP Google Scholar
Godoy-Martinez, Patricio C. Google Scholar
Correa, Benedito Google Scholar
Guarro, Josep Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Rovira & Virgili
Univ Austral Chile
Universidade de São Paulo (USP)
Abstract Aspergillus flavus is the second most common cause of aspergillosis infection in immunocompromised patients and is responsible for the production of aflatoxins. Little is known about the population structure of A. flavus, although recent molecular and phenotypic data seem to demonstrate that different genetic lineages exist within this species. the aim of this study was to carry out a morphological, physiological, and molecular analysis of a set of clinical and environmental isolates to determine whether this variability is due to species divergence or intraspecific diversity, and to assess whether the clinical isolates form a separate group. the amdS and omtA genes were more phylogenetically informative than the other tested genes and their combined analysis inferred three main clades, with no clear distinction between clinical and environmental isolates. No important morphological and physiological differences were found between the members of the different clades, with the exception of the assimilation of D-glucosamine, which differentiates the members of the clade II from the others. (C) 2012 the British Mycological Society. Published by Elsevier B.V. All rights reserved.
Keywords Acetamidase gene
Aspergillus flavus
O-methyltransferase gene
Language English
Sponsor Spanish 'Ministerio de Educacion y Ciencia'
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number Spanish 'Ministerio de Educacion y Ciencia': CGL 2009-08698/BOS
CAPES: SWE 4150-08-2
CNPq: GM/GD 142051/2007-1
Date 2012-11-01
Published in Fungal Biology. Oxford: Elsevier B.V., v. 116, n. 11, p. 1146-1155, 2012.
ISSN 1878-6146 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1146-1155
Access rights Closed access
Type Article
Web of Science ID WOS:000312414300003

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