Pre-surgical predictors for psychiatric disorders following epilepsy surgery in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis

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dc.contributor.author Araujo Filho, Gerardo Maria de [UNIFESP]
dc.contributor.author Mazetto, Lenon [UNIFESP]
dc.contributor.author Gomes, Francinaldo Lobato [UNIFESP]
dc.contributor.author Marinho, Murilo Martinez [UNIFESP]
dc.contributor.author Tavares, Igor Melo [UNIFESP]
dc.contributor.author Sales Ferreira Caboclo, Luis Otavio [UNIFESP]
dc.contributor.author Centeno, Ricardo Silva [UNIFESP]
dc.contributor.author Targas Yacubian, Elza Marcia [UNIFESP]
dc.date.accessioned 2016-01-24T14:27:57Z
dc.date.available 2016-01-24T14:27:57Z
dc.date.issued 2012-11-01
dc.identifier http://dx.doi.org/10.1016/j.eplepsyres.2012.05.005
dc.identifier.citation Epilepsy Research. Amsterdam: Elsevier B.V., v. 102, n. 1-2, p. 86-93, 2012.
dc.identifier.issn 0920-1211
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/35460
dc.description.abstract Psychiatric outcomes of patients submitted to epilepsy surgery have gained particular interest given the high prevalence of pre-surgical psychiatric disorders (PD) in this population. the present study aimed to verify the possible pre-surgical predictors for psychiatric disorders following epilepsy surgery in a homogeneous series of patients with refractory temporal lobe epilepsy and mesial temporal sclerosis (TLE-MTS). Data from 115 TLE-MTS patients (65 females; 56.5%) who underwent cortico-amygdalohippocampectomy were included. Pre- and post-surgical psychiatric evaluations were performed using DSM-IV criteria. Pre-surgical PD - particularly mood, anxiety and psychotic disorders - were diagnosed in 47 patients (40.8%). Twenty-seven patients (54% of those with pre-surgical PD) demonstrated a remission of psychiatric symptoms on post-surgical psychiatric evaluation. Eleven patients (9.6%) developed de novo PD. the presence of pre-surgical depression (OR= 3.32; p=0.008), pre-surgical interictal psychosis (OR = 4.39; p=0.009) and epileptiform discharges contralateral to the epileptogenic zone (OR = 2.73; p = 0.01) were risk factors associated with post-surgical PD. Although epilepsy surgery is considered to be the best treatment option for patients with refractory TLE-MTS, the relatively high psychiatric comorbidities observed in surgical candidates and their possible negative impact on post-surgical outcomes require a careful pre-surgical evaluation of clinical, sociodemographic and psychiatric factors. (C) 2012 Elsevier B.V. All rights reserved. en
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 86-93
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Epilepsy Research
dc.rights Acesso restrito
dc.subject Temporal lobe epilepsy en
dc.subject Mesial temporal sclerosis en
dc.subject Epilepsy surgery en
dc.subject Psychiatric disorders en
dc.subject Psychiatric outcome en
dc.title Pre-surgical predictors for psychiatric disorders following epilepsy surgery in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo UNIFESP, Dept Neurol & Neurosurg, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo UNIFESP, Dept Psychiat, Lab Interdisciplinar Neurociencias Clin LiNC, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo UNIFESP, Dept Neurol & Neurosurg, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo UNIFESP, Dept Psychiat, Lab Interdisciplinar Neurociencias Clin LiNC, São Paulo, Brazil
dc.identifier.doi 10.1016/j.eplepsyres.2012.05.005
dc.description.source Web of Science
dc.identifier.wos WOS:000311529400010



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