Dermatophyte-host relationship of a murine model of experimental invasive dermatophytosis

Dermatophyte-host relationship of a murine model of experimental invasive dermatophytosis

Author Venturini, James Google Scholar
Alvares, Anuska Marcelino Autor UNIFESP Google Scholar
Camargo, Marcela Rodrigues de Google Scholar
Marchetti, Camila Martins Google Scholar
Fraga-Silva, Thais Fernanda de Campos Google Scholar
Luchini, Ana Carolina Google Scholar
Arruda, Maria Sueli Parreira de Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Univ Fed Triangulo Mineiro
Abstract Recognizing the invasive potential of the dermatophytes and understanding the mechanisms involved in this process will help with disease diagnosis and with developing an appropriate treatment plan. in this report, we present the histopathological, microbiological and immunological features of a model of invasive dermatophytosis that is induced by subcutaneous infection of Trichophyton mentagrophytes in healthy adult Swiss mice. Using this model, we observed that the fungus rapidly spreads to the popliteal lymph nodes, spleen, liver and kidneys. Similar to the human disease, the lymph nodes were the most severely affected sites. the fungal infection evoked acute inflammation followed by a granulomatous reaction in the mice, which is similar to what is observed in patients. the mice were able to mount a Th1-polarized immune response and displayed IL-10-mediated immune regulation. We believe that the model described here will provide valuable information regarding the dermatophyte-host relationship and will yield new perspective for a better understanding of the immunological and pathological aspects of invasive dermatophytosis. (c) 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
Keywords Dermatophytes
Invasive dermatophytosis
Trichophyton mentagrophytes
Cellular immune response
Experimental dermatophytosis
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Fundação para o Desenvolvimento da UNESP (FUNDUNESP)
Date 2012-11-01
Published in Microbes and Infection. Amsterdam: Elsevier B.V., v. 14, n. 13, p. 1144-1151, 2012.
ISSN 1286-4579 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1144-1151
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000311017000004

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