Study of Heparin in Intestinal Ischemia and Reperfusion in Rats: Morphologic and Functional Evaluation

Study of Heparin in Intestinal Ischemia and Reperfusion in Rats: Morphologic and Functional Evaluation

Author Ghadie, Majid Mohamad Autor UNIFESP Google Scholar
Miranda-Ferreira, Regiane Autor UNIFESP Google Scholar
Taha, Nabiha Saadi Abrahão Autor UNIFESP Google Scholar
Maroso, A. S. Google Scholar
Moreti, R. J. Z. Google Scholar
Andraus, M. P. Google Scholar
Zempulski, P. Google Scholar
Monteiro, Hugo Pequeno Autor UNIFESP Google Scholar
Simões, Manuel de Jesus Autor UNIFESP Google Scholar
Fagundes, Djalma José Autor UNIFESP Google Scholar
Caricati-Neto, Afonso Autor UNIFESP Google Scholar
Taha, Murched Omar Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Fed Univ Great Dourados
Abstract To study whether treatment with heparin (HEP) attenuates intestinal dysfunction caused by ischemia (I) and reperfusion (R), rats were treated with HEP (100 U/kg intravenously) or saline solution (SS) before I (60 min), which was produced by occlusion of the superior mesenteric artery, and R (120 min). After I or I/R, we mounted 2-cm jejunal segment in an organ bath to study neurogenic contractions stimulated by electrical pulses or KCl, using a digital recording system. Thin jejunal slices were stained with hematoxylin and eosin for optical microscopy. Compared with the sham group, jejunal contractions were similar in the I + HEP and the I/R + HEP groups, but reduced in the I + SS and the I/R + SS groups. the jejunal enteric nerves were damaged in the I + SS and the I/R + SS, but not in the I + HEP and the I/R + HEP cohorts. These results suggested that HEP attenuated intestinal dysfunction caused by I and I/R.
Language English
Date 2012-10-01
Published in Transplantation Proceedings. New York: Elsevier B.V., v. 44, n. 8, p. 2300-2303, 2012.
ISSN 0041-1345 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 2300-2303
Origin http://dx.doi.org/10.1016/j.transproceed.2012.07.055
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000309736900012
URI http://repositorio.unifesp.br/handle/11600/35307

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