Long-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescents

Long-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescents

Author Lira, Fabio Santos de Autor UNIFESP Google Scholar
Rosa, Jose C. Autor UNIFESP Google Scholar
Pimentel, Gustavo D. Autor UNIFESP Google Scholar
Santos, Ronaldo V. Autor UNIFESP Google Scholar
Carnier, June Autor UNIFESP Google Scholar
Sanches, Priscila L. Autor UNIFESP Google Scholar
Piano, Aline de Autor UNIFESP Google Scholar
Souza, Claudio T. de Google Scholar
Tock, Lian Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Seelaender, Marilia Autor UNIFESP Google Scholar
Nascimento, Claudia Maria da Penha Oller do Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Damaso, Ana Raimunda Autor UNIFESP Google Scholar
Institution Dept Fisiol
Dept Biociencias
Dept Psicobiol
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Univ So Santa Catarina
Abstract Aim: the purpose of the present study was to assess the dietary fat intake, glucose, insulin, Homeostasis model assessment for insulin resistance HOMA-IR, and endotoxin levels and correlate them with adipokine serum concentrations in obese adolescents who had been admitted to long-term interdisciplinary weight-loss therapy.Design: the present study was a longitudinal clinical intervention of interdisciplinary therapy. Adolescents (n = 18, aged 15-19 y) with a body mass index >95th percentile were admitted and evaluated at baseline and again after 1 year of interdisciplinary therapy. We collected blood samples, and IL-6, adiponectin, and endotoxin concentrations were measured by ELISA. Food intake was measured using 3-day diet records. in addition, we assessed glucose and insulin levels as well as the homeostasis model assessment for insulin resistance (HOMA-IR).Results: the most important finding from the present investigation was that the long-term interdisciplinary lifestyle therapy decreased dietary fat intake and endotoxin levels and improved HOMA-IR. We observed positive correlations between dietary fat intake and endotoxin levels, insulin levels, and the HOMA-IR. in addition, endotoxin levels showed positive correlations with IL-6 levels, insulin levels and the HOMA-IR. Interestingly, we observed a negative correlation between serum adiponectin and both dietary fat intake and endotoxin levels.Conclusions: the present results indicate an association between dietary fat intake and endotoxin level, which was highly correlated with a decreased pro-inflammatory state and an improvement in HOMA-IR. in addition, this benefits effect may be associated with an increased adiponectin level, which suggests that the interdisciplinary therapy was effective in improving inflammatory pathways.
Keywords Obesity
Cytokines
Endotoxin
Insulin resistance
Interdisciplinary therapy
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2011/50356-0
FAPESP: 2011/50414-0
Date 2012-09-18
Published in Nutrition Journal. London: Biomed Central Ltd, v. 11, 7 p., 2012.
ISSN 1475-2891 (Sherpa/Romeo, impact factor)
Publisher Biomed Central Ltd
Extent 7
Origin http://dx.doi.org/10.1186/1475-2891-11-74
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000310462200001
URI http://repositorio.unifesp.br/handle/11600/35277

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