CD8(+) T-cell-mediated immunity against malaria: a novel heterologous prime-boost strategy

CD8(+) T-cell-mediated immunity against malaria: a novel heterologous prime-boost strategy

Author Soares, Irene S. Google Scholar
Francoso, Katia S. Google Scholar
Jampaulo, Vander O. Autor UNIFESP Google Scholar
Rodrigues, Mauricio M. Autor UNIFESP Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Evaluation of: Rodriguez D, Gonzalez-Aseguinolaza G, Rodriguez JR et al. Vaccine efficacy against malaria by the combination of porcine parvovirus-like particles and vaccinia virus vectors expressing CS of Plasmodium. PLoS ONE 7(4), e34445 (2012). Recently, a vaccine against malaria was successfully tested in a human Phase III trial. the efficacy of this vaccine formulation, based on the Plasmodium falciparum circumsporozoite protein, was approximately 50% and correlated with the presence of antibodies specific to the infective stages of the malaria parasites. Different strategies are being pursued to improve vaccine efficacy levels. One such strategy is the induction of specific cytotoxic T cells that can destroy the intracellular hepatocyte stages of the malaria parasite. in this study, a novel vaccination protocol was developed to elicit strong immune responses mediated by CD8(+) cytotoxic cells specific to the circumsporozoite protein. As proof-of-concept, the authors used the rodent malaria Plasmodium yoelii parasite. the vaccination strategy consisted of a heterologous prime-boost vaccination regimen involving porcine parvovirus-like particles for priming and the modified vaccinia virus Ankara for the booster immunization, both of which expressed the immunodominant CD8 epitope of the P. yoelii circumsporozoite protein. Results from this experimental model were extremely meaningful. This vaccination strategy led to a significant T-cell immune response mediated by CD8(+) multifunctional T effector and effector-memory cells. However, most importantly for the malaria vaccine development was the fact that following a sporozoite challenge, immunized mice eliminated more than 97% of the malaria parasites during the hepatocyte stages. These results confirm and extend a vast body of knowledge showing that a heterologous prime-boost vaccination strategy can elicit strong CD8(+) T-cell-mediated protective immunity and may increase the efficacy of malaria vaccines.
Keywords CD8(+) T cells
malaria vaccine
prime-boost vaccination
virus-like particle
Language English
Date 2012-09-01
Published in Expert Review of Vaccines. London: Expert Reviews, v. 11, n. 9, p. 1039-1041, 2012.
ISSN 1476-0584 (Sherpa/Romeo, impact factor)
Publisher Expert Reviews
Extent 1039-1041
Origin http://dx.doi.org/10.1586/ERV.12.82
Access rights Closed access
Type Article
Web of Science ID WOS:000312043400008
URI http://repositorio.unifesp.br/handle/11600/35262

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