Postprandial proximal gastric acid pocket and gastroesophageal reflux disease

Postprandial proximal gastric acid pocket and gastroesophageal reflux disease

Author Herbella, F. A. M. Autor UNIFESP Google Scholar
Vicentine, F. P. P. Autor UNIFESP Google Scholar
Silva, L. C. Autor UNIFESP Google Scholar
Patti, M. G. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Chicago
Abstract An unbuffered layer of acidity that escapes neutralization by food has been demonstrated in volunteers and gastroesophageal reflux disease patients. This postprandial proximal gastric acid pocket (PPGAP) is manometrically defined by the presence of acid reading (pH < 4) in a segment of the proximal stomach between nonacid segments distally (food) and proximally (lower esophageal sphincter or distal esophagus). the PPGAP may have important clinical implications; however, it is still poorly understood. Gastric anatomy and physiology seem to be important elements for PPGAP genesis. Gastric operations and acid suppression medications may decrease distal proximal intragastric acid reflux and help control gastroesophageal reflux.
Keywords acid
acid pocket
anatomy
gastroesophageal reflux
motility
Language English
Date 2012-09-01
Published in Diseases of the Esophagus. Hoboken: Wiley-Blackwell, v. 25, n. 7, p. 652-655, 2012.
ISSN 1120-8694 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 652-655
Origin http://dx.doi.org/10.1111/j.1442-2050.2011.01293.x
Access rights Closed access
Type Review
Web of Science ID WOS:000308712300012
URI http://repositorio.unifesp.br/handle/11600/35254

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