N-acetylcysteine as a potentially useful medication to prevent conversion to schizophrenia in at-risk individuals

N-acetylcysteine as a potentially useful medication to prevent conversion to schizophrenia in at-risk individuals

Author Asevedo, Elson Autor UNIFESP Google Scholar
Cunha, Graccielle R. Autor UNIFESP Google Scholar
Zugman, Andre Autor UNIFESP Google Scholar
Mansur, Rodrigo B. Autor UNIFESP Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Schizophrenia is a chronic and often severe psychotic disorder. Its causes include imbalances in mediators involved in neuroplasticity, apoptosis, cell resilience and dendritic arborization. Among these mediators, oxidative species are particularly relevant for the pathophysiology of the disease, and this is the rationale for experimental use of antioxidant medications, such as N-acetylcysteine (NAC). Onset of schizophrenia is usually preceded by a period of subtle and unspecific symptoms, the prodrome, in which preventive interventions could delay or even stop the progression to full-blown psychosis. in this article, we propose that NAC could be a useful medication to prevent evolution of schizophrenia in individuals at risk for psychosis.
Keywords N-acetylcysteine
neuroplasticity
oxidative species
psychosis
schizophrenia
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2012-08-01
Published in Reviews in the Neurosciences. Berlin: Walter de Gruyter & Co, v. 23, n. 4, p. 353-362, 2012.
ISSN 0334-1763 (Sherpa/Romeo, impact factor)
Publisher Walter de Gruyter & Co
Extent 353-362
Origin http://dx.doi.org/10.1515/revneuro-2012-0039
Access rights Closed access
Type Article
Web of Science ID WOS:000309969600002
URI http://repositorio.unifesp.br/handle/11600/35162

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