Can morphine interfere in the healing process during chronic stress?

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dc.contributor.author Egydio, F. [UNIFESP]
dc.contributor.author Ruiz, F. S. [UNIFESP]
dc.contributor.author Tomimori, J. [UNIFESP]
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.contributor.author Andersen, Monica Levy [UNIFESP]
dc.date.accessioned 2016-01-24T14:27:30Z
dc.date.available 2016-01-24T14:27:30Z
dc.date.issued 2012-08-01
dc.identifier http://dx.doi.org/10.1007/s00403-012-1261-1
dc.identifier.citation Archives of Dermatological Research. New York: Springer, v. 304, n. 6, p. 413-420, 2012.
dc.identifier.issn 0340-3696
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/35120
dc.description.abstract Technological advances, constant pressure, increased qualified demand, and other daily activities present in modern society result in increasingly stressful living conditions for the population. in the short term, the release of stress-related hormones can play a key role in the survival of an organism. However, it is well known that chronic exposure to cortisol can lead to many adverse effects. Several findings show immunological changes in response to chronic exposure to cortisol, in particular in skin integrity, which may interfere with the healing process. Morphine is an immunosuppressive drug, and when it is used chronically, it can lead to an increased incidence of infections and a delay in the healing process. the importance of opiates as analgesics in the medical setting is indisputable. However, there are a limited number of studies in this field. These investigations can provide further understanding of the mechanisms involved in the healing process in morphine-dependent individuals under chronic stress, which is a common condition in modern society. Furthermore, medical prescriptions of opiates are common among terminal patients, who frequently develop decubitus ulcers and bacterial infections. This review is aimed to provide a concise analysis of effects of morphine and stress on the healing process. en
dc.description.sponsorship Associacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 413-420
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Archives of Dermatological Research
dc.rights Acesso restrito
dc.subject Wound healing en
dc.subject Stress en
dc.subject Skin en
dc.subject Morphine en
dc.subject Cortisol en
dc.subject Sleep deprivation en
dc.title Can morphine interfere in the healing process during chronic stress? en
dc.type Resenha
dc.rights.license http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo UNIFESP, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo UNIFESP, Dept Dermatol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo UNIFESP, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo UNIFESP, Dept Dermatol, BR-04024002 São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 11/14462
dc.description.sponsorshipID FAPESP: 07/55445-6
dc.description.sponsorshipID FAPESP: 98/14303-3
dc.identifier.doi 10.1007/s00403-012-1261-1
dc.description.source Web of Science
dc.identifier.wos WOS:000306695300001



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