Short Duration Transient Visual Evoked Potentials in Glaucomatous Eyes

Short Duration Transient Visual Evoked Potentials in Glaucomatous Eyes

Author Prata, Tiago Santos Autor UNIFESP Google Scholar
Lima, Veronica C. Autor UNIFESP Google Scholar
De Moraes, Carlos Gustavo V. Google Scholar
Trubnik, Valerie Google Scholar
Derr, Peter Google Scholar
Liebmann, Jeffrey M. Google Scholar
Ritch, Robert Google Scholar
Tello, Celso Google Scholar
Institution New York Eye & Ear Infirm
New York Med Coll
Universidade Federal de São Paulo (UNIFESP)
Diopsys Inc
Abstract Purpose: To investigate the correlation between structural and functional damage in patients with asymmetric glaucoma using a newly developed short duration transient visual evoked potential (SD-tVEP) device.Methods: Twenty-five patients with visual acuity >= 20/30 and asymmetric visual field (VF) loss [inter-eye difference in mean deviation index (MD) of at least 3 dB] were enrolled. Patients underwent optical coherence tomography (OCT) for macular thickness measurement, scanning laser polarimetry with variable corneal compensation for retinal nerve fiber layer measurement, and SD-tVEP (10% and 85% Michelson contrast, acquisition time of 20 s) in both eyes within 2 months. We correlated VF MD and structural test results with SD-tVEP P100 latency and Delta Amplitude (N75-P100).Results: Using 10% contrast, there was a significant difference in SD-tVEP latency and amplitude between eyes with better and worse VF MD (P < 0.001). MD correlated significantly with both SD-tVEP parameters (r > 0.33, P <= 0.01). When using 85% contrast, SD-tVEP amplitude differed between eyes (P = 0.01) and MD values correlated significantly with amplitude results (r = 0.32, P = 0.01), but not with latency (P = 0.46). in eyes with more advanced VF loss, there was a positive and significant correlation between SD-tVEP amplitude (85% contrast) and macular thickness on OCT (r = 0.47, P = 0.01), but not with retinal nerve fiber layer measured with polarimetry (P = 0.26).Conclusions: in cases of asymmetric glaucoma, SD-tVEP results correlate significantly with the level of VF damage as measured by MD. in the eyes with more advanced VF loss, reduced SD-tVEP amplitude was associated with decreased macular thickness on OCT. These findings suggest that SD-tVEP may be a fast and objective method to assess or screen for functional damage in glaucomatous eyes.
Keywords glaucoma
visual evoked potential
optical coherence tomography
scanning laser polarimetry
Language English
Sponsor Diopsys, Inc
Date 2012-08-01
Published in Journal of Glaucoma. Philadelphia: Lippincott Williams & Wilkins, v. 21, n. 6, p. 415-420, 2012.
ISSN 1057-0829 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 415-420
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000308669900011

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